1026572-83-7

Basic information

• Product Name: H-Tyr(O-Pic)-NH-(CH₂)8-NH-Boc
• Synonyms: H-Tyr(O-Pic)-NH-(CH₂)8-NH-Boc
• CAS NO: 1026572-83-7
• Molecular Weight: 498.666
• Mol File: 1026572-83-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: H-Tyr(O-Pic)-NH-(CH₂)8-NH-Boc(CAS DataBase Reference)
• NIST Chemistry Reference: H-Tyr(O-Pic)-NH-(CH₂)8-NH-Boc(1026572-83-7)
• EPA Substance Registry System: H-Tyr(O-Pic)-NH-(CH₂)8-NH-Boc(1026572-83-7)

Safety Data

• Hazardous Substances Data: 1026572-83-7(Hazardous Substances Data)

Upstream product

• 325464-34-4 Fmoc-Tyr(O-Pic)-OH 
• 88829-82-7 tert-butyl N-(8-aminooctyl)carbamate 
• 395063-10-2 Fmoc-Tyr(O-Pic)-NH-(CH₂)8-NH-Boc 

Downstream Products

• 395063-14-6 (8-{2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-3-[4-(pyridin-4-ylmethoxy)-phenyl]-propionylamino}-octyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Structure-inhibitory activity relationship of plasmin and plasma kallikrein inhibitors

Based on the structure of Tra-Tyr(O-Pic)-octylamide, a portion of the octylamine was replaced with moieties bearing hydrophobic, basic or acidic groups. Replacement of the C-terminal residue with a moiety bearing a hydrophobic group gave the proper affinity of the inhibitor to both plasmin (PL) and plasma kallikrein (PK). While addition of a basic residue did not improve the affinity of the inhibitor, a carboxylic acid attached to the phenyl ring increased the PK selectivity of the inhibitor.