1026765-13-8

Basic information

• Product Name: N-(4-methoxyphenyl)-N,2,6-trimethylpyrimidin-4-amine
• Synonyms: N-(4-methoxyphenyl)-N,2,6-trimethylpyrimidin-4-amine
• CAS NO: 1026765-13-8
• Molecular Weight: 243.308
• Mol File: 1026765-13-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-methoxyphenyl)-N,2,6-trimethylpyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxyphenyl)-N,2,6-trimethylpyrimidin-4-amine(1026765-13-8)
• EPA Substance Registry System: N-(4-methoxyphenyl)-N,2,6-trimethylpyrimidin-4-amine(1026765-13-8)

Safety Data

• Hazardous Substances Data: 1026765-13-8(Hazardous Substances Data)

Upstream product

• 4472-45-1 4-chloro-2,6-dimethylpyrimidine 
• 5961-59-1 N-methyl-N-(4-methoxyphenyl)amine 
• 6622-92-0 4-hydroxy 2,6-dimethylpyrimidine 

Relevant articles and documents

Synthesis and evaluation of new 2-chloro-4-aminopyrimidine and 2,6-dimethyl-4-aminopyrimidine derivatives as tubulin polymerization inhibitors

Eighteen new 2-chloro-4-aminopyrimidine and 2,6-dimethyl-4-aminopyrimidine derivatives were synthesized and evaluated as tubulin polymerization inhibitor for the treatment of cancer. Among them, compounds 10, 17, 20 and 21 exhibited potent antiproliferative activities against five human cancer cell lines. Microtubule dynamics assay showed that compound 17 could effectively inhibit tubulin polymerization. Molecular docking studies were also carried out to understand the binding pattern. Further mechanism studies revealed that 17 could induce G2/M phase arrest, disrupt the organization of the cellular microtubule network and induce cell apoptosis and mitochondrial dysfunction.