1026922-74-6

Basic information

• Product Name: 8-benzyloxy-1-hydroxy-4,4-dimethyl-2-octene
• Synonyms: 8-benzyloxy-1-hydroxy-4,4-dimethyl-2-octene
• CAS NO: 1026922-74-6
• Molecular Weight: 262.392
• Mol File: 1026922-74-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-benzyloxy-1-hydroxy-4,4-dimethyl-2-octene(CAS DataBase Reference)
• NIST Chemistry Reference: 8-benzyloxy-1-hydroxy-4,4-dimethyl-2-octene(1026922-74-6)
• EPA Substance Registry System: 8-benzyloxy-1-hydroxy-4,4-dimethyl-2-octene(1026922-74-6)

Safety Data

• Hazardous Substances Data: 1026922-74-6(Hazardous Substances Data)

Upstream product

• 1027404-66-5 3,3-dimethyl-5-oxo-1-trityloxypentane 
• 170798-81-9 2,2-dimethyl-8-trityloxy-pentan-1-ol 
• 681-57-2 2,2-dimethylglutaric acid 
• 3121-82-2 2,2-dimethylpentane-1,5-diol 
• 1026271-96-4 8-benzyloxy-4,4-dimethyl-1-trityloxy-2-octene 

Downstream Products

• 170798-96-6 methyl 4,4-dimethyl-8-(p-toluenesulfonyloxy)octanoate 
• 1027289-70-8 methyl 8-benzyloxy-1-hydroxy-4,4-dimethyl-2-octenoate 
• 1026362-53-7 (Z)-8-Benzyloxy-4,4-dimethyl-oct-5-enoic acid 

Relevant articles and documents

18F-labeled octanoates as potential agents for cerebral fatty acid studies. The influence of 4-substitution and the fluorine position on biodistribution.

In order to understand the structural features that might lead to an in vivo radiotracer for studying cerebral fatty acid metabolism, 8-[18F]fluorooctanoate derivatives with methyl or gem-dimethyl branching at the C4 position have been prepared. 3-[18F]Fluoro- and 4-[18F]fluorooctanoic acid have also been synthesized for studying the influence of the fluorine position on the in vivo behavior of 18F-labeled octanoic acid analogs. Radiochemical synthesis was achieved by the nucleophilic displacement of a tosylate or mesylate precursor with [18F]fluoride ion. Tissue distribution studies in rats showed low cerebral uptakes of these 18F-labeled fatty acid analogs with poor brain-to-blood ratios. 3-[18F]Fluorooctanoic acid showed considerable defluorination, evident as a high bone activity level. The initial uptake of activity in the brain after injection of ethyl 8-[18F]fluoro-4-methyloctanoate and 4-[18F]-fluorooctanoic acid remained virtually unchanged over an extended time period, similar to that previously observed for the unbranched analogs, ethyl 8-[18F]fluorooctanoate and its free acid. In contrast, the 4-gem-dimethyl branched analog was rapidly and preferentially taken up by the liver. It was shown in the metabolite analysis that labeled metabolites produced from 8-[18F]fluoro-4-methyloctanoic acid were found in blood, and that they could enter the brain to a significant degree. Thus, the present studies showed that radioactivity retention in the brain in the case of the 4-methyl branched analog was mainly attributable to its radioactive metabolites.