102729-51-1

Basic information

• Product Name: 3-Phenyl-6-trifluoromethylquinoxalinyl-1H-2-one
• Synonyms: 3-Phenyl-6-trifluoromethylquinoxalinyl-1H-2-one
• CAS NO: 102729-51-1
• Molecular Weight: 290.244
• Mol File: 102729-51-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-Phenyl-6-trifluoromethylquinoxalinyl-1H-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Phenyl-6-trifluoromethylquinoxalinyl-1H-2-one(102729-51-1)
• EPA Substance Registry System: 3-Phenyl-6-trifluoromethylquinoxalinyl-1H-2-one(102729-51-1)

Safety Data

• Hazardous Substances Data: 102729-51-1(Hazardous Substances Data)

Upstream product

• 71-23-8 propan-1-ol 
• 13726-52-8 diethyl N-(p-aminobenzoyl)-L-glutamate 
• 102729-52-2 2-chloro-3-phenyl-6-trifluoromethylquinoxaline 
• 219555-78-9 (S)-2-[4-(3-Phenyl-6-trifluoromethyl-quinoxalin-2-yloxy)-benzoylamino]-pentanedioic acid diethyl ester 
• 219555-63-2 4-(3-phenyl-6-trifluoromethyl-quinoxalin-2-yloxy)-benzoic acid methyl ester 
• 64-17-5 ethanol 
• 611-73-4 Benzoylformic acid 
• 368-71-8 4-(trifluoromethyl)-1,2-phenylenediamine 

Downstream Products

• 102729-52-2 2-chloro-3-phenyl-6-trifluoromethylquinoxaline 

Relevant articles and documents

Quinoxalin-2-one derivatives, compositions which protect useful plants and comprise these derivatives, and processes for their preparation and their use

Compounds of the formula (I) and salts thereof in which X is O or S; (Y)n=n substituents Y, n is 0, 1, 2, 3 or 4, R1 is H, OH, NH2, (C1-C4)-alkylamino, di-[(C1-C4)-alkyl]amino or optionally substituted (C1-C10)-alkyl, (C3-C10)-alkenyl, (C3-C10)-alkynyl or (C1-C10)-alkoxy, (C3-C10)-cycloalkyl, (C4-C10)-cycloalkenyl, aryl or heterocyclyl, R2 is H or optionally substituted (C1-C10)-alkyl, (C3-C10)-alkenyl, (C3-C10)-alkynyl, (C3-C10)-cycloalkyl, (C4-C10)-cycloalkenyl, aryl or heterocyclyl, where the radicals Y are as defined in claim 1 are suitable for use as safeners for crop plants or useful plants against the phytotoxic actions of agrochemicals such as pesticides in these plants.

Quinoxaline chemistry. Part 7. 2-[aminobenzoates]- and 2- [aminobenzoylglutamate]-quinoxalines as classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity

Thirty-three quinoxalines bearing an aminobenxoyl or aminobenzoylglutammate group on position 2 and various substituents on position 3,6,7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10-5 and 10-4 molar concentrations. Interesting selectivities were also recorded between 10-8 and 10-6. Among the series examined one compound (29) which was the most active also exhibited both in vitro anti-HIV protection and antifungal activity while in other two (31.37) the antifungal activity was prevailing.