1027394-73-5

Basic information

• Product Name: N-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2,2,2-trifluoro-acetamide
• CAS NO: 1027394-73-5
• Molecular Weight: 319.399
• Mol File: 1027394-73-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2,2,2-trifluoro-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2,2,2-trifluoro-acetamide(1027394-73-5)
• EPA Substance Registry System: N-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2,2,2-trifluoro-acetamide(1027394-73-5)

Safety Data

• Hazardous Substances Data: 1027394-73-5(Hazardous Substances Data)

Upstream product

• 591-27-5 m-Hydroxyaniline 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 121942-75-4 3-[(tert-butyldimethylsilyl)oxy]aniline 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 1027586-26-0 N-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2,2,2-trifluoro-N-methyl-acetamide 
• 14703-69-6 3-(N-methylamino)phenol 
• 23040-64-4 3-hydroxy-N-methyl-N-nitrosoaniline 

Relevant articles and documents

Synthesis and protein tyrosine phosphatase inhibitory activity of dephostatin analogs

We have synthesized derivatives of dephostatin, a protein tyrosine phosphatase (PTPase) inhibitor, to study the structure-activity relationships of this inhibitor. Inactive analogs revealed some insight into structural requirements for PTPase inhibitory activity of dephostatin. Both a nitroso group and phenolic hydroxyl groups were found to be essential for the inhibitory activity. Among the dephostatin derivatives synthesized, one of the regioisomers of dephostatin showed PTPase inhibitory activity equivalent to that of dephostatin, and also had increased stability.