1027511-28-9

Basic information

• Product Name: C₂₈H₂₂O₅S₂N₄Cl₂
• Synonyms: C₂₈H₂₂O₅S₂N₄Cl₂
• CAS NO: 1027511-28-9
• Molecular Weight: 629.544
• Mol File: 1027511-28-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₂₂O₅S₂N₄Cl₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₂₂O₅S₂N₄Cl₂(1027511-28-9)
• EPA Substance Registry System: C₂₈H₂₂O₅S₂N₄Cl₂(1027511-28-9)

Safety Data

• Hazardous Substances Data: 1027511-28-9(Hazardous Substances Data)

Upstream product

• 133-13-1 ethyl diethyl malonate 
• 42039-81-6 5-ethyl-2-thiobarbituric acid 
• 878979-66-9 C₁₃H₁₃O₄SN₃ 
• 1025916-63-5 C₂₇H₂₅O₈S₃N₃ 
• 3215-64-3 2,6-dichlorophenylacetonitrile 

Relevant articles and documents

Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6- (arylcarbonyl or α-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

A series of novel S-DABO analogues (S-DABOs, 1) were synthesized and evaluated as inhibitors of human immunodeficiency virus type-1 (HIV-1). Key structural modifications included replacement of the 6-arylmethyl group by a 6-arylcarbonyl or 6-(α-cyanoarylmethyl) group. Most of the compounds showed only micromolar potency against HIV-1 in MT-4 cells in vitro, though two of them (3e and 3g) were unusually potent (IC50 = 0.09 and 0.002 μM, respectively) and selective (SI = 1500 and 4600, respectively). Structure-activity relationships among the newly synthesized S-DABOs are discussed.