1027542-53-5

Basic information

• Product Name: (R)-tert-butyl 3-(benzyloxymethyl)pyrrolidine-1-carboxylate
• Synonyms: (R)-tert-butyl 3-(benzyloxymethyl)pyrrolidine-1-carboxylate
• CAS NO: 1027542-53-5
• Molecular Weight: 291.39
• Mol File: 1027542-53-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-tert-butyl 3-(benzyloxymethyl)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-tert-butyl 3-(benzyloxymethyl)pyrrolidine-1-carboxylate(1027542-53-5)
• EPA Substance Registry System: (R)-tert-butyl 3-(benzyloxymethyl)pyrrolidine-1-carboxylate(1027542-53-5)

Safety Data

• Hazardous Substances Data: 1027542-53-5(Hazardous Substances Data)

Upstream product

• 99724-15-9 methyl 5-oxo-1-((S)-1-phenylethyl)pyrrolidine-3-(R)-carboxylate 
• 100-39-0 benzyl bromide 
• 138108-72-2 tert-butyl (R)-3-hydroxymethylpyrrolidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 99735-47-4 (3R)-1-[(R)-1-phenylethyl]-3-(hydroxymethyl)pyrrolidine 

Downstream Products

• 223453-22-3 (3R)-4-(3-benzyloxymethyl)pyrrolidin-1-ylbutanal dimethyl acetal 

Relevant articles and documents

Transition-metal-free synthesis of 3-(1-pyrrolidinyl)quinolines and 3-(1-pyrrolidinyl)quinoline 1-oxides via a one-pot reaction of 3-(1-pyrrolidinyl)crotonates with nitrobenzenes

A carbanion of tert-butyl 3-(1-pyrrolidinyl)crotonate adds to nitrobenzenes to form σH-adducts, which in the presence of pivaloyl chloride and triethylamine are converted into 3-(1-pyrrolidinyl)quinolines or 3-(1-pyrrolidinyl)quinoline 1-oxides depending on the nitrobenzene structure. This is the first methodology in which a quinoline ring is constructed from a substrate bearing a pyrrolidinyl ring. Starting from optically pure enamines, the method allows synthesis of the corresponding chiral products without racemisation.

3-[2-(Pyrrolidin-1-yl)ethyl]indoles and 3-[3-(Piperidin-1- yl)propyl]indoles: Agonists for the h5-HT(1D) receptor with high selectivity over the h5-HT(1B) subtype

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