1027646-67-8

Basic information

• Product Name: (E)-2-{3-[(Dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynoic acid ethyl ester
• Synonyms: (E)-2-{3-[(Dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynoic acid ethyl ester
• CAS NO: 1027646-67-8
• Molecular Weight: 476.731
• Mol File: 1027646-67-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-2-{3-[(Dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-{3-[(Dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynoic acid ethyl ester(1027646-67-8)
• EPA Substance Registry System: (E)-2-{3-[(Dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynoic acid ethyl ester(1027646-67-8)

Safety Data

• Hazardous Substances Data: 1027646-67-8(Hazardous Substances Data)

Upstream product

• 140-88-5 ethyl acrylate 
• 54848-86-1 chloromethyl(2-methylphenyl)dimethylchlorosilane 
• 626-02-8 3-Iodophenol 
• 95-46-5 2-methylphenyl bromide 
• 591-20-8 3-Bromophenol 
• 78629-21-7 (E)-6,6-dimethyl-2-hepten-4-ynyl bromide 
• 180071-79-8 ethyl-3-<((2-methylphenyl)dimethylsilyl)methoxy>propinoate 
• 180071-77-6 (E)-ethyl-3-<((2-methylphenyl)dimethylsilyl)methoxy>-propenoate 
• 96251-92-2 (E)-3-(3-hydroxyphenyl)acrylic acid ethyl ester 

Downstream Products

• 180071-78-7 Methanesulfonic acid (E)-2-{3-[(dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynyl ester 
• 180071-76-5 2-<3-<((2-methylphenyl)dimethylsilyl)methoxy>benzyl>-8,8-dimethyl-non-4-ene-6-ynol 

Relevant articles and documents

A convergent and straightforward synthetic method to prepare deaza-analogs of squalene epoxidase inhibitors

A general route to deaza-analogs of squalene epoxidase inhibitors of general formula A is described using a very convergent synthetic scheme illustrated by the preparation of compound 2b. A Heck reaction, and an enolate condensation with an appropriate electrophile are the key steps of the expedient elaboration of 2b or analogs.