1027905-92-5

Basic information

• Product Name: 2-Amino-N-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4,5-difluoro-benzamide
• Synonyms: 2-Amino-N-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4,5-difluoro-benzamide
• CAS NO: 1027905-92-5
• Molecular Weight: 423.37
• Mol File: 1027905-92-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Amino-N-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4,5-difluoro-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-N-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4,5-difluoro-benzamide(1027905-92-5)
• EPA Substance Registry System: 2-Amino-N-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4,5-difluoro-benzamide(1027905-92-5)

Safety Data

• Hazardous Substances Data: 1027905-92-5(Hazardous Substances Data)

Upstream product

• 126917-48-4 (2R,3R)-3-Azido-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol 
• 83506-93-8 2-amino-4,5-difluorobenzoic acid 
• 127000-91-3 (2R,3R)-3-Amino-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol 

Downstream Products

• 187949-57-1 (1R,2R)-7-Amino-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-6-fluoro quinazolin-4(3H)-one 

Relevant articles and documents

Design, synthesis, and structure-activity relationship studies of novel triazole agents with strong antifungal activity against Aspergillus fumigatus

The incidence of invasive fungal infections has dramatically increased for several decades. In order to discover novel antifungal agents with broad spectrum and anti-Aspergillus efficacy, a series of novel triazole derivatives containing 1,2,3-benzotriazin-4-one was designed and synthesized. Most of the compounds exhibited stronger in vitro antifungal activities against tested fungi than fluconazole. Moreover, 6m showed comparable antifungal activity against seven pathogenic strains as voriconazole and albaconazole, especially against Aspergillus fumigatus (MIC = 0.25 μg/ml), and displayed moderate antifungal activity against fluconazole-resistant strains of Candida albicans. A clear SAR study indicated that compounds with groups at the 7-position resulted in novel antifungal triazoles with more effectiveness and a broader-spectrum.