1028090-91-6

Basic information

• Product Name: [2-((E)-2-nitro-vinyl)-phenyl]-pyrrolidine
• Synonyms: [2-((E)-2-nitro-vinyl)-phenyl]-pyrrolidine
• CAS NO: 1028090-91-6
• Molecular Weight: 218.255
• Mol File: 1028090-91-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [2-((E)-2-nitro-vinyl)-phenyl]-pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: [2-((E)-2-nitro-vinyl)-phenyl]-pyrrolidine(1028090-91-6)
• EPA Substance Registry System: [2-((E)-2-nitro-vinyl)-phenyl]-pyrrolidine(1028090-91-6)

Safety Data

• Hazardous Substances Data: 1028090-91-6(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 58028-74-3 2-pyrrolidin-1-ylbenzaldehyde 

Downstream Products

• 1028090-95-0 1-{2-[(Z)-2-nitrovinyl]phenyl}-pyrrolidine 

Relevant articles and documents

Suppression of TRIF-dependent signaling pathway of toll-like receptors by (E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine

Toll-like receptors (TLRs) play an important role in the recognition of microbial pathogens and induce innate immune responses. The recognition of microbial components by TLRs triggers the activation of myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing adapter inducing interferon-β (TRIF)-dependent downstream signaling pathways. Previously, we synthesized (E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine (NVPP), which contains a nitrovinyl-phenyl and pyrrolidine. To evaluate the therapeutic potential of NVPP, its effect on signal transduction via the TRIF-dependent pathway of TLRs induced by lipopolysaccharide (LPS) or polyinosinic- polycytidylic acid (poly[I:C]) was examined. NVPP inhibited LPS or poly[I:C]-induced activation of nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3), and the phosphorylation of IRF3, as well as inhibiting the activation of interferon-inducible genes such as interferon inducible protein-10 (IP-10). These results suggest that NVPP can modulate TRIF-dependent signaling pathways of TLRs, potentially resulting in effective therapeutics for chronic inflammatory diseases.

Scope and limitations of the T-reaction employing some functionalized C-H-acids and naturally occurring secondary amines

Scope and limitations of the T-reaction with emphasis on using chiral, natural products as starting materials to prepare novel chiral heterocycles is studied and the diastereoselective introduction of newly formed stereocenters is explained via proposed mechanisms.