1028257-06-8

Basic information

• Product Name: 4-{[2-(2-Cyano-3-oxo-cyclopentyl)-ethyl]-ethyl-amino}-benzoic acid ethyl ester
• CAS NO: 1028257-06-8
• Molecular Weight: 328.411
• Mol File: 1028257-06-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-{[2-(2-Cyano-3-oxo-cyclopentyl)-ethyl]-ethyl-amino}-benzoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{[2-(2-Cyano-3-oxo-cyclopentyl)-ethyl]-ethyl-amino}-benzoic acid ethyl ester(1028257-06-8)
• EPA Substance Registry System: 4-{[2-(2-Cyano-3-oxo-cyclopentyl)-ethyl]-ethyl-amino}-benzoic acid ethyl ester(1028257-06-8)

Safety Data

• Hazardous Substances Data: 1028257-06-8(Hazardous Substances Data)

Upstream product

• 26815-64-5 ethyl 4-benzoate 
• 1027415-66-2 4-[Ethyl-(2-methanesulfonyloxy-ethyl)-amino]-benzoic acid ethyl ester 
• 170799-80-1 ethyl N-(4-ethoxycarbonylphenyl)-N-ethylaminoacetate 
• 170799-78-7 N-(4-ethoxycarbonylphenyl)-N-ethylaminoacetic acid 
• 170799-75-4 ethyl 4-benzoate 
• 94-09-7 p-aminoethylbenzoate 
• 91624-95-2 5-oxo-1-cyclopentene-1-carbonitrile 
• 170799-73-2 ethyl 4-benzoate 

Downstream Products

• 1054608-47-7 (S)-2-(4-{[2-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-ethyl]-ethyl-amino}-benzoylamino)-pentanedioic acid diethyl ester 
• 170799-63-0 ethyl 4-pyrimidin-5-yl)ethyl>-N-ethylamino>benzoate 
• 170799-57-2 4-pyrimidin-5-yl)ethyl>-N-ethylamino>benzoic acid 
• 170799-68-5 ethyl 4--N-ethylamino>benzoate 

Relevant articles and documents

Novel 6-5 fused ring heterocycle antifolates with potent antitumor activity: Bridge modifications and heterocyclic benzoyl isosters of 2,4-diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine antifolate

Structural modifications of an extremely potent inhibitor of dihydrofolate reductase (DHFR) activity and tumor cell growth, N-[4-[3-(2,4-diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidin-5-yl)propyl ]benzoyl]-L-glutamic acid (1), have led to the synthesis of