1028459-20-2

Basic information

• Product Name: (1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-amine
• Synonyms: (1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-amine
• CAS NO: 1028459-20-2
• Molecular Weight: 361.419
• Mol File: 1028459-20-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-amine(1028459-20-2)
• EPA Substance Registry System: (1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-amine(1028459-20-2)

Safety Data

• Hazardous Substances Data: 1028459-20-2(Hazardous Substances Data)

Upstream product

• 146137-76-0 2-Fluoro-5-iodo-benzaldehyde 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 113322-99-9 tert-butyl ((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)carbamate 
• 108-86-1 bromobenzene 
• 492-41-1 (1R,2S)-norephedrine 
• 1025762-98-4 1-(4-fluorophenyl)-5-iodo-1H-indazole 

Downstream Products

• 1028458-64-1 N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]cyclopropanesulfonamide 
• 1028459-13-3 1-methylimidazole-4-sulfonic acid N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]amide 
• 1028459-14-4 3,5-dimethylisooxazole-4-sulfonic acid N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]amide 
• 1034147-99-3 N-((1S,2R)-2-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-methyl-2-phenylethyl)cyclopropanecarboxamide 
• 1034149-16-0 l-{(1S,2R)-2-{[1-(4-fluorophenyl)-1H-indazole-5-yl]oxy}-1-methyl-2-phenylethyl}-3-(2-furylmethyl)thiourea 
• 1034149-08-0 1-(cyclopentyl)-3-{(1S,2R)-2-[1-(4-fluorophenyl)-1H-indazole-5-yloxy]-1-methyl-2-phenyl-ethyl}urea 
• 1034149-34-2 N-{(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl}-5-methyl-[1,3,4]oxadiazol-2-carboxamide 
• 1034149-14-8 1-((R)-1,2-dimethylpropyl)-3-{(1S,2R)-2-[1-(4-fluorophenyl)-1H-indazole-5-yloxy]-1-methyl-2-phenylethyl}urea 
• 1034149-10-4 1-{(1S,2R)-2-{[1-(4-fluorophenyl)-1H-indazole-5-yl]oxy}-1-methyl-2-phenylethyl}-3-(2-furylmethyl)urea 
• 1034149-12-6 ethyl N-{[(1S,2R)-2-{[1-(4-fluorophenyl)-lH-indazole-5-yl]oxy}-1-methyl-2-phenylethyl]carbamoyl}glycinate 

Relevant articles and documents

Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases

A class of potent, nonsteroidal, selective indazole ether-based glucocorticoid receptor modulators (SGRMs) was developed for the inhaled treatment of respiratory diseases. Starting from an orally available compound with demonstrated anti-inflammatory activity in rat, a soft-drug strategy was implemented to ensure rapid elimination of drug candidates to minimize systemic GR activation. The first clinical candidate 1b (AZD5423) displayed a potent inhibition of lung edema in a rat model of allergic airway inflammation following dry powder inhalation combined with a moderate systemic GR-effect, assessed as thymic involution. Further optimization of inhaled drug properties provided a second, equally potent, candidate, 15m (AZD7594), that demonstrated an improved therapeutic ratio over the benchmark inhaled corticosteroid 3 (fluticasone propionate) and prolonged the inhibition of lung edema, indicating potential for once-daily treatment.

INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS

Compounds of formula (I) or a pharmaceutically acceptable salt thereof; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the glucocorticoid receptor in a warm blooded animal).