1028492-15-0Relevant articles and documents
A new silicon lewis acid for highly enantioselective Mannich reactions of aliphatic ketone-derived hydrazones
Notte, Gregory T.,Leighton, James L.
, p. 6676 - 6677 (2008/12/22)
The first general method for the highly enantioselective Mannich reaction of aliphatic ketimines is reported. A new, second generation chiral silane Lewis acid has been developed that promotes the reaction between ketone-derived hydrazones and silyl ketene acetals, providing the β,β-disubstituted β-amino esters with good enantioselectivity even for the hydrazone derived from 2-butanone (methyl vs ethyl, 91% ee). Several examples are provided, including a reaction with a substituted (propanoate-derived) silyl ketene acetal. Copyright