10286-78-9Relevant articles and documents
Modular Continuous Flow Synthesis of Imatinib and Analogues
Fu, Wai Chung,Jamison, Timothy F.
supporting information, p. 6112 - 6116 (2019/08/26)
A modular continuous flow synthesis of imatinib and analogues is reported. Structurally diverse imatinib analogues are rapidly generated using three readily available building blocks via a flow hydration/chemoselective C-N coupling sequence. The newly developed continuous flow hydration and amidation modules each exhibit a broad scope with good to excellent yields. Overall, the method described does not require solvent switches, in-line purifications, or packed-bed apparatuses due to the judicious manipulation of flow setups and solvent mixtures.
Palladium-catalyzed addition of arylboronic acids to isocyanates
Kianmehr, Ebrahim,Rajabi, Azam,Ghanbari, Mohammad
scheme or table, p. 1687 - 1688 (2009/09/05)
The addition of arylboronic acids to isocyanates catalyzed by palladium acetate in the presence of triphenylphosphine as the ligand is described.