10289-08-4Relevant articles and documents
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Yuki et al.
, (1958)
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Synthesis of alkyl-modified poly(sodium glutamate)s for preparation of polymer-protein nanoparticles in combination with N,N,N-trimethyl chitosan
Pahovnik, David,Grujic, Milijana,Cegnar, Mateja,Ker?, Janez,?agar, Ema
, p. 2976 - 2985 (2014)
The negatively charged, water-soluble, hydrophobically modified poly(sodium glutamate)s containing different amounts of alkyl grafts were synthesized. First, poly(γ-benzyl-L-glutamate) was prepared by ring-opening polymerization of the corresponding N-carboxyanhydride, which was in the next step aminolysed with octylamine. After removal of the remaining benzyl protective groups, the alkyl-modified poly(sodium glutamate)s [P(Glu-oa)] were obtained and, together with the oppositely charged N,N,N-trimethyl chitosan (TMC), used for the preparation of nanoparticles (NPs) of a recombinant granulocyte colony-stimulating factor (GCSF) protein by polyelectrolyte complexation method. It is observed that, beside electrostatic interaction, the hydrophobic grafts on poly(sodium glutamate)s significantly contribute to association efficiency (AE) with GCSF protein. The addition of TMC solution to the dispersion of GCSF/P(Glu-oa) complexes results in formation of much more defined NPs with high AE and final protein loading.
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Yamashita,Tani
, p. 406,407 (1974)
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Synthesis and characterization of ultrathin metal coordination Prussian blue nanoribbons
Bao, Suping,Qin, Wangping,Wu, Qihua,Liang, Guodong,Zhu, Fangming,Wu, Qing
, p. 5242 - 5246 (2013)
Ultrathin metal coordination Prussian blue (PB) nanoribbons with tunable width have been successfully synthesized. The morphology and microstructure of PB nanoribbons are characterized using UV-vis, FT-IR, AFM, TEM and XRD. PB nanoribbons synthesized possess an ultrathin thickness of approximately 1 nm and narrow width. The width of PB ribbons can be tuned by varying the chain length of polymeric precursors. The PB hybrid nanoribbons synthesized exhibit enhanced thermal stability and electrochemical activity. The merit of narrow and tunable width as well as ultrathin thickness of PB hybrid nanoribbons along with enhanced thermal stability and electrochemical activity makes them potentially useful in nano-devices, biosensors and so on.
Biodegradable supramolecular micellesviahost-guest interaction of cyclodextrin-terminated polypeptides and adamantane-terminated polycaprolactones
Pottanam Chali, Sharafudheen,Azhdari, Suna,Galstyan, Anzhela,Gr?schel, André H.,Ravoo, Bart Jan
supporting information, p. 9446 - 9449 (2021/09/22)
Biodegradable supramolecular micelles were prepared exploiting the host-guest interaction of cyclodextrin and adamantane. Cyclodextrin-initiated polypeptides acted as the hydrophilic corona, whereas adamantane-terminated polycaprolactones served as the hydrophobic core.
Polyionic type micelle shielding system with electric charge turnover function and preparation method thereof
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Paragraph 0101-0102, (2020/06/24)
The invention provides a polyionic type micelle shielding system with reversible charges. The polyionic type micelle shielding system is formed by a compound shown as formula (III) and cis-diamminedichloroplatinum through coordination. According to the polyionic type micelle shielding system with the reversible charges, cis-diamminedichloroplatinum is supported under a coordination action, a support material is good in biocompatibility and solubility, the nano-support is enriched at a tumor tissue part through an EPR (enhanced permeability and retention effect), a shell with a shielding capability is removed under the condition of pH at the tumor tissue part, a positively charged cis-diamminedichloroplatinum supported core is exposed, endocytosis is facilitated by the positively charged core, and after the cis-diamminedichloroplatinum supported core enters a cell, the drug cis-diamminedichloroplatinum with anti-tumor performance is released by the cis-diamminedichloroplatinum supportedcore.
Preparation method and application of folic acid-targeted dual-drug-loaded nanoparticles
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Paragraph 0016; 0059-0061, (2020/01/14)
The invention relates to a preparation method and application of folic acid-targeted dual-drug-loaded nanoparticles, and can effectively solve problems that anti-tumor drugs are low in water solubility, serious in toxic and side effects, lack of targeting, etc. A technical solution is to prepare dendrimers PLD and polyglutamic acid (PGA), and paclitaxel, gemcitabine and folic acid are loaded on the PGA to obtain PGA-PTX, PGA-GEM and PGA-FA. The four materials in an aqueous solution are attracted to each other by positive and negative charges, and self-assembled to form the nanoparticles, and particle diameters of the nanoparticles are about (190 plus or minus 15) nm. The nanoparticles enter tumor cells and release the paclitaxel and the gemcitabine through combination of the folic acid andfolic acid receptors on surfaces of the tumor cells, thereby inhibiting proliferation of the tumor cells and promoting apoptosis. The drug-loaded nanoparticles can effectively inhibit growth of tumorcells 4T1 and have a better inhibitory effect on tumor models of the 4T1 cells in vivo.
