102904-35-8Relevant articles and documents
Facile three-component synthesis of substituted quinolines catalyzed by iridium(III) complex
Nakajima, Takayuki,Inada, Takashi,Igarashi, Takeyuki,Sekioka, Tadashi,Shimizu, Isao
, p. 1941 - 1949 (2006)
A convenient and efficient synthesis of substituted quinolines via a simple one-pot reaction of an aniline, an aromatic aldehyde, and an enolizable aliphatic aldehyde in the presence of the iridium catalyst [IrCl 2H(cod)]2 under oxygen as an oxidant was developed. The reaction proceeds with Mannich-type imine formation followed by nucleophilic addition to give β-amino aldehydes. Dehydrative cyclization takes place to give dihydroquinoline, which is then dehydrogenated by aerobic oxidation to give 2-aryl-3-alkylquinolines. Dialkylquinolines were obtained by the reaction with anilines and aliphatic aldehydes in good yields.
Method of treatment
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, (2008/06/13)
This invention describes a method of treating inflammation in warm-blooded animals by topically administering an effective amount of a benzylideneaniline derivative, and the compositions therefore.
