102908-42-9

Basic information

• Product Name: 2-AMINO-BETA-OXO-BENZENEPROPANENITRILE
• Synonyms: 2-AMINO-BETA-OXO-BENZENEPROPANENITRILE
• CAS NO: 102908-42-9
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.17
• Mol File: 102908-42-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 366.6±22.0 °C(Predicted)
• Appearance: /
• Density: 1.203±0.06 g/cm3(Predicted)
• PKA: 6.93±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-BETA-OXO-BENZENEPROPANENITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-BETA-OXO-BENZENEPROPANENITRILE(102908-42-9)
• EPA Substance Registry System: 2-AMINO-BETA-OXO-BENZENEPROPANENITRILE(102908-42-9)

Safety Data

• Hazardous Substances Data: 102908-42-9(Hazardous Substances Data)

Upstream product

• 75-05-8 acetonitrile 
• 87-25-2 2-ethoxycarbonylaniline 
• 606-27-9 methyl 2-nitrobenzoate 
• 610-14-0 2-nitrobenzyl chloride 
• 141342-35-0 (Z)-2-Cyano-3-hydroxy-3-(2-nitrophenyl)acrylsaeureethylester 
• 5234-26-4 N-(2-acetylphenyl)acetamide 
• 4688-64-6 1-[2-(acetylamino)phenyl]-2-bromoethanone 
• 118-48-9 isatoic anhydride 
• 58585-01-6 1-(2-amino-phenyl)-2-bromo-ethanone 
• 151-50-8 potassium cyanide 
• 40017-83-2 3-(2-Nitrophenyl)-3-oxopropionsaeurenitril 

Downstream Products

• 141259-11-2 4-oxo-2-phenyl-1,4-dihydroquinoline-3-carbonitrile 

Relevant articles and documents

Solid-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones

Cyanoacetic acid was loaded on Wang resin and C-acylated using acid anhydrides and triethylamine as base. Resin cleavage with concomitant decarboxylation produces β-keto nitriles. In the case of isatoic anhydrides, the resin-bound acylated intermediates undergo cyclative cleavage upon heating, leading to 4hydroxyquinolin-2(1H)-ones.

Tumor-targeted hypoxic azo aromatic nitrogen oxide-chloroethyintrosoureas coupled molecule, preparation method and application thereof

The invention provides a tumor-targeted hypoxic azo aromatic nitrogen oxide-chloroethyintrosoureas coupled molecule, a preparation method and application thereof. The coupled molecule has a structureshown as the general formula (I) in the specification, wherein R is one of OH, NH2, N(CH3)2, NHCH3, N(CH2CH3)2, and NHCH2CH3; R1 is one of H, CH3, OCH3, NO2, Cl and Br; and n is an integer of 2-6. Theazo aromatic nitrogen oxide-chloroethyintrosoureas coupled molecule provided by the invention can play a cytotoxic role and an AGT inhibitor role in low oxygen areas, and inhibit the growth of tumorcells, and also has the characteristics of hypoxia targeting, tumor resistance, drug tolerance resistance, antiangiogenesis and the like.

Synthesis of 2,3-disubstituted 4-oxoquinolines and 3-substituted fused 4-oxoquinolines

Seven 2,3-disubstituted 4-oxoquinolines were prepared via two methods. In the first one 2,3-disubstituted 4-oxoquinolines were prepared via the condensation of 2-amino-α-cyanoacetophenone with substituted phthalic anhydrides, while in the second method the fused isoindolo[2,1-a]quinolines and pyrrolo[1,2-a]quinolines were first prepared and then converted to 4-oxoquinolines. X-Ray crystal structure analysis of ethyl 2-[3-cyano-4-oxo-2-quinolyl]benzoate is reported.