10292-60-1

Basic information

• Product Name: Phenol, 2-cyclopropyl-
• Synonyms: AKOS BAR-1540;2-CYCLOPROPYLPHENOL;Phenol, 2-cyclopropyl-;2-Cyclopropylphenol 98%;(2-Hydroxyphenyl)cyclopropane
• CAS NO: 10292-60-1
• Molecular Formula: C₉H₁₀O
• Molecular Weight: 134.18
• Product Categories: Aromatics, Intermediates
• Mol File: 10292-60-1.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 169.8±9.0 °C(Predicted)
• Appearance: /
• Density: 1.158±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.31±0.30(Predicted)
• CAS DataBase Reference: Phenol, 2-cyclopropyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-cyclopropyl-(10292-60-1)
• EPA Substance Registry System: Phenol, 2-cyclopropyl-(10292-60-1)

Safety Data

• Hazardous Substances Data: 10292-60-1(Hazardous Substances Data)

Usage

Description

Phenol, 2-cyclopropyl-, is an organic compound characterized by the presence of a cyclopropyl group attached to a phenol molecule. This unique structure endows it with specific chemical and biological properties, making it a versatile compound in various applications.

Uses

Used in Pharmaceutical Industry:
Phenol, 2-cyclopropyl-, is used as a reagent for the preparation of imidazolines, which exhibit significant adrenergic α2C-Agonism/α2A-Antagonism. These imidazolines are important in the development of medications targeting the adrenergic system, which plays a crucial role in the regulation of various physiological processes, including blood pressure, heart rate, and stress response.
Used in Chemical Synthesis:
Phenol, 2-cyclopropyl-, is also utilized as an intermediate in the preparation of Cirazoline Hydrochloride (C497400), a potent α-1 adrenergic receptor agonist and an even more potent α-2 receptor antagonist. Phenol, 2-cyclopropylhas potential applications in the treatment of various medical conditions, such as hypotension and other cardiovascular disorders, where modulation of adrenergic receptors is necessary.

Upstream product

• 1745-81-9 o-Allylphenol 
• 24892-63-5 1-allyloxy-2-iodobenzene 
• 594-19-4 tert.-butyl lithium 
• 3158-73-4 2-cyclopropylaniline 
• 28987-74-8 (RS)-6-acetoxy-6-cyclopropylcyclohexa-2,4-dien-1-one 
• 873-49-4 cyclopropylbenzene 
• 65006-97-5 [(1-chlorocyclopropyl)sulfinyl]benzene 
• 108-95-2 phenol 
• 77-76-9 2,2-dimethoxy-propane 
• 470693-88-0 3-cyclopropylcyclohexa-3,5-diene-1,2-diol 
• 555-24-8 lithium phenolate 
• 60333-75-7 O-allyl-2-bromophenol 
• 138142-60-6 Trimethyl(2-vinylphenoxy)silane 
• 695-84-1 2-allylphenol 

Downstream Products

• 499234-73-0 3-chloro-6-(2-cyclopropylphenoxy)-pyridazine 1-oxide 
• 499234-72-9 6-chloro-3-(2-cyclopropylphenoxy)-pyridazine 1-oxide 
• 1043871-14-2 4-bromo-2-cyclopropylphenol 
• 1062617-20-2 1,2-bis(3-cyclopropyl-4-(difluoromethoxy)phenyl)ethane-1,2-dione 
• 1062617-16-6 1,2-bis(3-cyclopropyl-4-(difluoromethoxy)phenyl)ethyne 
• 1062617-13-3 4-bromo-2-cyclopropyl-1-(difluoromethoxy)benzene 
• 1602681-28-6 6-(2-cyclopropylphenoxy)-4-(6-methylpyridin-2-ylamino)pyridazine-3-carboxamide 
• 749929-58-6 4-Bromo-2-cyclopropyl-1-methoxy-benzene 
• 1253420-71-1 (S)-(+)-2-(1-(2-cyclopropylphenoxy)ethyl)-4,5-dihydro-1H-imidazole 
• 1253420-67-5 (S)-(-)-methyl-2-(2-cyclopropylphenoxy)propanoate 
• 1253420-72-2 (R)-(-)-2-(1-(2-cyclopropylphenoxy)ethyl)-4,5-dihydro-1H-imidazole 
• 1253420-68-6 (R)-(+)-methyl 2-(2-cyclopropylphenoxy)propanoate 

Relevant articles and documents

Novel photohydration of non-conjugated aryl/olefin bichromophores within cyclodextrin cavities

Cyclodextrin media are used to achieve photochemical water addition to isolated, acyclic double bonds via intramolecular interaction with excited arenes.

Isomerization of 2-(2-propenoxy)phenyllithium: Tandem anionic cyclization-γ-elimination

2-(2-Propenoxy)phenyllithium (1), which may be prepared from the corresponding iodide by low-temperature lithium-iodine exchange, rearranges on warming in the presence of TMEDA via 5-exo cyclization to (2,3-dihydrobenzofuranyl)methyllithium (2) followed by γ-elimination to give variable amounts of the lithium salt of 2-(cyclopropyl)phenol (3).

Diastereo- and enantioselective carbolithiation of allyl o-lithioaryl ethers. New chiral cyclopropane derivatives

(matrix presented) Different allyl 2-lithioaryl ethers undergo a tandem carbolithiation/γ-elimination in Et2OH-MEDA affording o-cyclopropyl phenol or naphthol derivatives in a diastereoselective manner. The use of (-)-sparteine as a chiral liga

5H-PYRROLO[3,4-￡>]PYRAZIN-7-AMINE DERIVATIVES INHIBITORS OF BETA-SECRETASE

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NEW COMPOUNDS 574

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