102921-92-6

Basic information

• Product Name: (2-(Methylthio)pyriMidin-4-yl)Methanol
• Synonyms: (2-(Methylthio)pyriMidin-4-yl)Methanol;2-(methylthio)-4-Pyrimidinemethanol;(2-methylsulfanylpyrimidin-4-yl)methanol
• CAS NO: 102921-92-6
• Molecular Formula: C₆H₈N₂OS
• Molecular Weight: 156.20552
• Mol File: 102921-92-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 322.8±17.0 °C(Predicted)
• Appearance: /
• Density: 1.30±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.19±0.10(Predicted)
• CAS DataBase Reference: (2-(Methylthio)pyriMidin-4-yl)Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-(Methylthio)pyriMidin-4-yl)Methanol(102921-92-6)
• EPA Substance Registry System: (2-(Methylthio)pyriMidin-4-yl)Methanol(102921-92-6)

Safety Data

• Hazardous Substances Data: 102921-92-6(Hazardous Substances Data)

Usage

General Description

(2-(Methylthio)pyriMidin-4-yl)Methanol is a chemical compound that belongs to the class of pyrimidines, which are organic compounds that contain a heterocyclic ring structure. The (2-(Methylthio)pyriMidin-4-yl)Methanol molecule consists of a pyrimidine ring with a methylthio group attached to the second position and a hydroxyl group attached to the third position. It is likely to have biological activity due to its structural similarity to other pyrimidine-based molecules, and it may be used in pharmaceutical research and drug development. The exact properties and potential uses of (2-(Methylthio)pyriMidin-4-yl)Methanol would need to be further investigated through experimental studies.

Upstream product

• 1126-44-9 2-methylsulfanylpyrimidine-4-carboxylic acid 
• 180869-36-7 4-dimethoxymethyl-2-methylsulfanylpyrimidine 
• 1074-68-6 4-formyl-2-(methylthio)pyrimidine 
• 49844-90-8 4-Chloro-2-methylthiopyrimidine 
• 50593-92-5 5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid 
• 123061-69-8 4-tert-butyldiphenylsilyloxymethyl-2-methylthiopyrimidine 
• 123061-68-7 2-methylthio-4-thexyldimethylsilyloxymethylpyrimidine 
• 123061-67-6 4-tert-butyldimethylsilyloxymethyl-2-methylthiopyrimidine 

Downstream Products

• 914094-62-5 3-bromo-5-ethoxy-4-(2-methylsulfanyl-pyrimidin-4-ylmethoxy)-benzaldehyde 
• 944902-34-5 4-(chloromethyl)-2-methylsulfanylpyrimidine 

Relevant articles and documents

Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor

Myeloid cell leukemia 1 (Mcl-1) has emerged as an attractive target for cancer therapy. It is an antiapoptotic member of the Bcl-2 family of proteins, whose upregulation in human cancers is associated with high tumor grade, poor survival, and resistance to chemotherapy. Here we report the discovery of our clinical candidate S64315, a selective small molecule inhibitor of Mcl-1. Starting from a fragment derived lead compound, we have conducted structure guided optimization that has led to a significant (3 log) improvement of target affinity as well as cellular potency. The presence of hindered rotation along a biaryl axis has conferred high selectivity to the compounds against other members of the Bcl-2 family. During optimization, we have also established predictive PD markers of Mcl-1 inhibition and achieved both efficient in vitro cell killing and tumor regression in Mcl-1 dependent cancer models. The preclinical candidate has drug-like properties that have enabled its development and entry into clinical trials.

NEW THIENOPYRIMIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R12, X, A and n are as defined in the description.

Novel Sulphur-Containing Cyclic Urea Derivatives, Preparation Thereof and Pharmaceutical Use Thereof as Kinase Inhibitors

The disclosure relates to compounds of formula (I): wherein Ra, Rb, R, and n are as defined in the disclosure, to pharmaceutical compositions comprising said compounds, and to processes for making and methods of using the same.