1029885-24-2Relevant articles and documents
A model for light-triggered porphyrin anticancer prodrugs based on an o-nitrobenzyl photolabile group
Lin, Weiying,Peng, Daiwei,Wang, Bin,Long, Lingliang,Guo, Cancheng,Yuan, Jinbin
, p. 793 - 796 (2008)
A model for light-triggered porphyrin anticancer prodrug 1 was designed and synthesized. Upon photolysis, prodrug 1 can efficiently liberate the anticancer drug tegafur. The MTT assay demonstrates that prodrug 1 is significantly less toxic than its parent drug tegafur, and 1 can release tegafur upon photoactivation in vitro. The light-triggered porphyrin anti-cancer prodrug technique developed herein may find useful applications in chemotherapy to minimize the side effects of anticancer drugs because of the tumor affinity property of porphyrin and the light-controllable anticancer drug dosing. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.