1030021-60-3Relevant articles and documents
Synthesis and anti-HIV activity of 5-haloethynyl and 5-(1,2-dihalo)vinyl analogues of AZT and FLT
Joubert, Nicolas,Amblard, Franck,Rapp, Kimberly L.,Schinazi, Raymond F.,Agrofoglio, Luigi A.
, p. 4444 - 4452 (2008)
In this paper, we report the synthesis of hitherto unknown 5-haloethynyl and 5-(1,2-dihalo)vinyluracil nucleoside analogues of the anti-HIV AZT, and FLT drugs. The key step of those syntheses is a Pd(0) cross-coupling at C5 position under Sonogashira cond