103024-80-2

Basic information

• Product Name: N²-(p-anisyldiphenylmethyl)-9-<<(p-anisyldiphenylmethoxy)-3-(p-toluenesulfonyloxy)-2-propoxy>methyl>-guanine
• Synonyms: N²-(p-anisyldiphenylmethyl)-9-<<(p-anisyldiphenylmethoxy)-3-(p-toluenesulfonyloxy)-2-propoxy>methyl>-guanine
• CAS NO: 103024-80-2
• Molecular Weight: 954.116
• Mol File: 103024-80-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N²-(p-anisyldiphenylmethyl)-9-<<(p-anisyldiphenylmethoxy)-3-(p-toluenesulfonyloxy)-2-propoxy>methyl>-guanine(CAS DataBase Reference)
• NIST Chemistry Reference: N²-(p-anisyldiphenylmethyl)-9-<<(p-anisyldiphenylmethoxy)-3-(p-toluenesulfonyloxy)-2-propoxy>methyl>-guanine(103024-80-2)
• EPA Substance Registry System: N²-(p-anisyldiphenylmethyl)-9-<<(p-anisyldiphenylmethoxy)-3-(p-toluenesulfonyloxy)-2-propoxy>methyl>-guanine(103024-80-2)

Safety Data

• Hazardous Substances Data: 103024-80-2(Hazardous Substances Data)

Upstream product

• 88110-86-5 9-[({1-hydroxy-3-[(4-methoxyphenyl)-diphenylmethoxy]propan-2-yl}oxy)methyl]-2-{[(4-methoxyphenyl)diphenylmethyl]amino}-6,9-dihydro-1H-purin-6-one 
• 98-59-9 p-toluenesulfonyl chloride 
• 73-40-5 2-amino-1,9-dihydro-6H-purin-6-one 
• 82410-32-0 ganciclovir 
• 82410-31-9 9-<<2-(benzyloxy)-1-<(benzyloxy)methyl>ethoxy>methyl>guanine 
• 18602-85-2 2,6,9-tris(trimethylsilyl)guanine 
• 14470-28-1 mono-4-methoxytrityl chloride 

Downstream Products

• 103024-81-3 N²-(p-anisyldiphenylmethyl)-9-<<1-(p-anisyldiphenylmethoxy)-3-azido-2-propoxy>methyl>guanine 
• 718633-32-0 N¹-methyl-N²-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethyl)-3-fluoro-2-propoxy]-methyl]guanine 
• 269716-58-7 N²-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-fluoro-2-propoxy]methyl]guanine 
• 718633-30-8 N¹-methyl-N²-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-(p-toluene-sulfonyloxy)-2-propoxy]methyl]guanine 

Relevant articles and documents

Efficient synthesis of 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) and 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG)

A new, high radiochemical yield synthesis of [18F]FHBG and [18F]FHPG, the most popular imaging agents currently in use for monitoring gene therapy using positron emission tomography (PET), is reported in this work. Protection of sens

Novel radiosynthesis of PET HSV-tk gene reporter probes [ 18F]FHPG and [18F]FHBG employing dual Sep-Pak SPE techniques

Positron emission tomography (PET) herpes simplex virus thymidine kinase (HSV-tk) gene reporter probes 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy) methyl]guanine ([18F]FHPG) and 9-(4-[18F]fluoro-3- hydroxymethylbutyl)guanine ([18F]FHBG) were prepared by nucleophilic substitution of the appropriate tosylated precursors with [18F]KF/ Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified dual Silica Sep-Pak solid-phase extraction (SPE) method in 15-30% radiochemical yield.

Synthesis and anti-herpes-virus activity of acyclic 2'-deoxyguanosine analogues related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine

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