103024-95-9Relevant articles and documents
Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs
Frich, Camilla Kaas,Krüger, Franziska,Walther, Raoul,Domar, Cecilie,Andersen, Anna H.F.,Tvilum, Anne,Dagn?s-Hansen, Frederik,Denton, Paul W.,Tolstrup, Martin,Paludan, S?ren R.,Münch, Jan,Zelikin, Alexander N.
, p. 298 - 310 (2019)
Albumin is a highly successful tool of drug delivery providing drastically extended body and blood residence time for the associated cargo, but it only traffics single drug copies at a time. In turn, macromolecular prodrugs (MP) are advantaged in carrying
Synthesis and antiviral evaluation of 1-O-hexadecylpropanediol-3-P- acyclovir: Efficacy against HSV-1 infection in mice
Beadle, James R.,Kini, Ganesh D.,Aldern, Kathy A.,Gardner, Michael F.,Wright, Kristine N.,Rybak, Rachel J.,Kern, Earl R.,Hosteller, Karl Y.
, p. 471 - 479 (2007/10/03)
We synthesized, 1-O-hexadecylpropanediol-3-P-acyclovir, an orally bioavailable lipid prodrug of acyclovir and evaluated it for in vitro and in vivo activity against herpes simplex virus infections. Although 1-O- hexadecylpropanediol-3-P-acyclovir was less