1030471-15-8

Basic information

• Product Name: p-tert-butyl-α,α,α-trifluoromethoxybenzene
• Synonyms: p-tert-butyl-α,α,α-trifluoromethoxybenzene
• CAS NO: 1030471-15-8
• Molecular Weight: 218.219
• Mol File: 1030471-15-8.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: p-tert-butyl-α,α,α-trifluoromethoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: p-tert-butyl-α,α,α-trifluoromethoxybenzene(1030471-15-8)
• EPA Substance Registry System: p-tert-butyl-α,α,α-trifluoromethoxybenzene(1030471-15-8)

Safety Data

• Hazardous Substances Data: 1030471-15-8(Hazardous Substances Data)

Upstream product

• 507-19-7 t-butyl bromide 
• 456-55-3 1-trifluoromethoxybenzene 
• 1035797-66-0 benzoic acid trifluoromethyl ester 
• 253185-03-4 tert-butylbenzene 
• 407-14-7 1-bromo-4-(trifluoromethoxy)benzene 
• 75-24-1 trimethylaluminum 
• 677-22-5 tert-butylmagnesium chloride 
• 1435486-09-1 ethyl (4-tert-butylphenoxy)(fluoro)acetate 
• 98-54-4 para-tert-butylphenol 
• 953090-88-5 2-fluoro-2-(4-(trifluoromethyl)phenoxy)acetic acid 
• 953091-35-5 ethyl 2-[4-(tert-butyl)phenoxy]-2,2-difluoroacetate 
• 75-15-0 carbon disulfide 
• 17688-83-4 2,5-tert-butyl-4-methyl-phenol 
• 106-48-9 4-chloro-phenol 

Downstream Products

• 18412-68-5 (4-tert-butylphenyl)trimethylsilane 

Relevant articles and documents

Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

The synthesis of mono-, di-, and trifluoromethyl aryl ethers by fluorodecarboxylation of the corresponding carboxylic acids is reported. AgF2induces decarboxylation of aryloxydifluoroacetic acids, and AgF, either generated in situ or added separately, serves as a source of fluorine to generate the fluorodecarboxylation products. The addition of 2,6-difluoropyridine increased the reactivity of AgF2, thereby increasing the range of functional groups and electronic properties of the aryl groups that are tolerated. The reaction conditions used for the formation of trifluoromethyl aryl ethers also served to form difluoromethyl and monofluoromethyl aryl ethers.

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Redox-Neutral TEMPO Catalysis: Direct Radical (Hetero)Aryl C?H Di- and Trifluoromethoxylation

Applications of TEMPO. catalysis for the development of redox-neutral transformations are rare. Reported here is the first TEMPO.-catalyzed, redox-neutral C?H di- and trifluoromethoxylation of (hetero)arenes. The reaction exhibits a broad substrate scope, has high functional-group tolerance, and can be employed for the late-stage functionalization of complex druglike molecules. Kinetic measurements, isolation and resubjection of catalytic intermediates, UV/Vis studies, and DFT calculations support the proposed oxidative TEMPO./TEMPO+ redox catalytic cycle. Mechanistic studies also suggest that Li2CO3 plays an important role in preventing catalyst deactivation. These findings will provide new insights into the design and development of novel reactions through redox-neutral TEMPO. catalysis.

Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow

The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison t