103085-91-2

Basic information

• Product Name: 1-(7-chloroquinolin-4-yl)-4-<4-(N,N'-dimethoxycarbonylguanidino)phenyl>piperazine
• Synonyms: 1-(7-chloroquinolin-4-yl)-4-<4-(N,N'-dimethoxycarbonylguanidino)phenyl>piperazine
• CAS NO: 103085-91-2
• Molecular Weight: 496.953
• Mol File: 103085-91-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(7-chloroquinolin-4-yl)-4-<4-(N,N'-dimethoxycarbonylguanidino)phenyl>piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(7-chloroquinolin-4-yl)-4-<4-(N,N'-dimethoxycarbonylguanidino)phenyl>piperazine(103085-91-2)
• EPA Substance Registry System: 1-(7-chloroquinolin-4-yl)-4-<4-(N,N'-dimethoxycarbonylguanidino)phenyl>piperazine(103085-91-2)

Safety Data

• Hazardous Substances Data: 103085-91-2(Hazardous Substances Data)

Upstream product

• 34840-23-8 1,3-Dicarbomethoxy-S-methylisothiourea 
• 103086-11-9 4-(4-aminophenyl)-1-(7-chloroquinolin-4-yl)piperazine 
• 86-98-6 4,7-dichloroquinoline 
• 6269-89-2 1-(4-Nitrophenyl)piperazine 
• 103086-12-0 1-(7-chloroquinolin-4-yl)-4-(4-nitrophenyl)piperazine 

Relevant articles and documents

Synthesis of some new 7-chloro-4-substituted quinolines as potential antiparasitic agents. I

The synthesis of 7-chloro-4-(substituted phenoxyquinolines, 7-chloro-4-(substituted phenylamino)quinolines and 7-chloro-4-(4-substituted phenylthio and sulfonyl)quinolines and 1-(7-chloroquinolin-4-yl)-4-substituted-piperazines has been carried out starting from 4,7-dichloroquinoline. The compounds were tested for their antimalarial activity against Plasmodium berghei in mice, antihookworm activity against Ancylostoma cylanicum in hamsters and anticestode activity against Hymenolepis nana in rats but none of them showed significant activity. When tested against Litomosoides carinii infection in cotton rats, two of the substituted piperazine compounds led to a 100% reduction of microfilariae in blood at an i.p. dose of 30 mg/kg given for 6 days.