103086-07-3Relevant articles and documents
Synthesis of some new 7-chloro-4-substituted quinolines as potential antiparasitic agents. I
Abuzar,Dubey,Sharma
, p. 5 - 8 (2007/10/02)
The synthesis of 7-chloro-4-(substituted phenoxyquinolines, 7-chloro-4-(substituted phenylamino)quinolines and 7-chloro-4-(4-substituted phenylthio and sulfonyl)quinolines and 1-(7-chloroquinolin-4-yl)-4-substituted-piperazines has been carried out starting from 4,7-dichloroquinoline. The compounds were tested for their antimalarial activity against Plasmodium berghei in mice, antihookworm activity against Ancylostoma cylanicum in hamsters and anticestode activity against Hymenolepis nana in rats but none of them showed significant activity. When tested against Litomosoides carinii infection in cotton rats, two of the substituted piperazine compounds led to a 100% reduction of microfilariae in blood at an i.p. dose of 30 mg/kg given for 6 days.