103094-33-3

Basic information

• Product Name: (-)-2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-(methoxycarbonyl)-3-<(2(S)-methoxy-2-phenethoxy)carbonyl>-6-methyl-1,4-dihydropyridine
• Synonyms: (-)-2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-(methoxycarbonyl)-3-<(2(S)-methoxy-2-phenethoxy)carbonyl>-6-methyl-1,4-dihydropyridine
• CAS NO: 103094-33-3
• Molecular Weight: 541.003
• Mol File: 103094-33-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (-)-2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-(methoxycarbonyl)-3-<(2(S)-methoxy-2-phenethoxy)carbonyl>-6-methyl-1,4-dihydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-(methoxycarbonyl)-3-<(2(S)-methoxy-2-phenethoxy)carbonyl>-6-methyl-1,4-dihydropyridine(103094-33-3)
• EPA Substance Registry System: (-)-2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-(methoxycarbonyl)-3-<(2(S)-methoxy-2-phenethoxy)carbonyl>-6-methyl-1,4-dihydropyridine(103094-33-3)

Safety Data

• Hazardous Substances Data: 103094-33-3(Hazardous Substances Data)

Upstream product

• 66051-01-2 (S)-2-methoxy-2-phenylethanol 
• 103069-49-4 2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 103069-48-3 2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-3-(2-cyanoethoxycarbonyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 103069-47-2 2-cyanoethyl 4-(2-azidoethoxy)-3-oxobutanoate 

Downstream Products

• 103129-81-3 (R)-2-[(2-aminoethoxy)methyl]4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester 
• 125639-89-6 2-<(2-azidoethoxy)methyl>-4(R)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine 

Relevant articles and documents

Determination of the absolute configuration of the active amlodipine enantiomer as (-)-S: A correction

The active (-) enantiomer of amlodipine was originally reported to have R configuration. This does not concur with other 1,4-dihydropyridines with known absolute configuration. This configuration has now been determined by X-ray structural analysis using (1S)-camphanic acid and (S)-2-methoxy-2- phenylethanol as chiral probes. Both determinations gave the S configuration for the amlodipine (-) enantiomer with the greater Ca-antagonistic activity.