103175-85-5

Basic information

• Product Name: Benzamide, N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-pentyl-
• CAS NO: 103175-85-5
• Molecular Formula: C22H21N5O3
• Molecular Weight: 403.44
• Mol File: 103175-85-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-pentyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-pentyl-(103175-85-5)
• EPA Substance Registry System: Benzamide, N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-pentyl-(103175-85-5)

Safety Data

• Hazardous Substances Data: 103175-85-5(Hazardous Substances Data)

Upstream product

• 26311-45-5 4-pentylbenzoic acid 
• 110683-22-2 8-amino-4-oxo-2-(5-1H-tetrazolyl)-4H-1-benzopyran 
• 538-68-1 pentylbenzene 
• 6853-57-2 4-pentylbenzaldehyde 

Relevant articles and documents

New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships

(p-Amylcinnamoyl)anthranilic acid (3a) had moderate antagonist activities against LTD4-induced smooth muscle contraction on guinea pig ileum and LTC4-induced bronchoconstriction in anesthetized guinea pigs. Modifications were made in the hydrophobic part (cinnamoyl moiety) and the hydrophilic part (anthranilate moiety) of 3a. A series of 8-(benzoylamino)-2-tetrazol-5-yl-1,4-benzodioxans and 8-(benzoylamino)-2-tetrazol-5-yl-4-oxo-4H-1-benzopyrans were revealed to be potent antagonists of leukotrienes C4 and D4. Among both series, ONO-RS-347 (18k) and ONO-RS411 (19h) were the most potent and orally active antagonists, respectively. Structure-activity relationships are discussed.