103213-40-7

Basic information

• Product Name: GLUTARYL-GLY-ARG-AMC HCL
• Synonyms: N-GLUTARYL-GLY-ARG-7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE;GLUTARYL-GLY-ARG-AMC HCL;GLUTARYL-GLYCYL-L-ARGININE 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE;N-GLUTARYL-GLY-ARG 7-AMIDO-4-*METHYLCOUM ARIN HYDROC;N-Glutaryl-Gly-Arg-7-amino-4-methylcoumarin hydrobromide;Glutaryl-Gly-Arg-AMC·HCl≥ 97% HPLC)
• CAS NO: 103213-40-7
• Molecular Formula: C23H31ClN6O7
• Molecular Weight: 538.98
• Product Categories: Coagulation Proteins and ReagentsEnzyme Substrates;Plasma&Blood Proteins;Protease Substrates;Proteins and Derivatives;Substrates by Enzyme;Urokinase;UrokinaseEnzyme Substrates
• Mol File: 103213-40-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 976.4oC at 760 mmHg
• Flash Point: 544.3oC
• Appearance: /
• Vapor Pressure: 0mmHg at 25°C
• Storage Temp.: −20°C
• CAS DataBase Reference: GLUTARYL-GLY-ARG-AMC HCL(CAS DataBase Reference)
• NIST Chemistry Reference: GLUTARYL-GLY-ARG-AMC HCL(103213-40-7)
• EPA Substance Registry System: GLUTARYL-GLY-ARG-AMC HCL(103213-40-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 103213-40-7(Hazardous Substances Data)

Usage

Description

GLUTARYL-GLY-ARG-AMC HCL, also known as Glutaryl-glycyl-L-arginine 7-Amido-4-methylcoumarin Hydrochloride, is a fluorogenic substrate primarily used for the detection and measurement of urokinase activity. It is a white crystalline powder with unique chemical properties that allow it to emit fluorescence upon cleavage by urokinase, making it a valuable tool in various applications.

Uses

Used in Pharmaceutical and Biomedical Research:
GLUTARYL-GLY-ARG-AMC HCL is used as a research tool for studying the activity and function of urokinase, a serine protease enzyme that plays a crucial role in various physiological and pathological processes. By monitoring the fluorescence emitted upon substrate cleavage, researchers can gain insights into urokinase's role in processes such as fibrinolysis, cell migration, and tissue remodeling.
Used in Diagnostic Applications:
In the field of diagnostics, GLUTARYL-GLY-ARG-AMC HCL serves as a valuable substrate for the detection and quantification of urokinase activity in biological samples. This can be particularly useful in the assessment of various conditions, such as thrombotic disorders, where abnormal urokinase activity may be indicative of underlying health issues.
Used in Drug Development:
GLUTARYL-GLY-ARG-AMC HCL is also employed in the development of new drugs targeting urokinase or related enzymes. By using this substrate in high-throughput screening assays, researchers can identify potential drug candidates that modulate urokinase activity, leading to the discovery of novel therapeutic agents for the treatment of various diseases.
Used in Quality Control and Standardization:
In the pharmaceutical industry, GLUTARYL-GLY-ARG-AMC HCL is utilized for quality control and standardization of urokinase-containing products. By measuring the fluorescence emitted upon substrate cleavage, manufacturers can ensure that their products meet the required specifications and maintain consistent activity levels.

InChI:InChI=1/C23H30N6O7.ClH/c1-13-10-21(34)36-17-11-14(7-8-15(13)17)28-22(35)16(4-3-9-26-23(24)25)29-19(31)12-27-18(30)5-2-6-20(32)33;/h7-8,10-11,16H,2-6,9,12H2,1H3,(H,27,30)(H,28,35)(H,29,31)(H,32,33)(H4,24,25,26);1H