103213-49-6 Usage
Description
GLU-GLY-VAL-ASN-ASP-ASN-GLU-GLU-GLY-PHE-PHE-SER-ALA-ARG, also known as Fibrinopeptide B (FPB), is a peptide fragment produced during the cleavage of fibrinogen by thrombin to fibrin monomer. It is cleaved off from the N-terminal of the fibrinogen β chain and consists of 14 amino acids. This peptide plays a crucial role in the coagulation and fibrinolytic processes in the body.
Uses
Used in Coagulation and Fibrinolytic Activity:
GLU-GLY-VAL-ASN-ASP-ASN-GLU-GLU-GLY-PHE-PHE-SER-ALA-ARG is used as an indicator of coagulation and fibrinolytic activity. It helps in monitoring and assessing the balance between clot formation and dissolution in the body, which is essential for maintaining proper blood flow and preventing excessive clotting or bleeding.
Used in Mass Spectrometry:
GLU-GLY-VAL-ASN-ASP-ASN-GLU-GLU-GLY-PHE-PHE-SER-ALA-ARG is also useful for the tuning and calibration of electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) mass spectrometers. These instruments are widely used in various fields, including proteomics, metabolomics, and drug discovery, to analyze and identify molecules based on their mass-to-charge ratio. By using FPB as a calibration standard, researchers can ensure accurate and reliable measurements in their experiments.
Biochem/physiol Actions
Fibrin formation is an essential part in wound healing and inflammation. Fibrinopeptide B (FPB) can also cause chemotactic migration of neutrophils, without the simultaneous release of lysosome enzymes. It is produced during the coagulation of fibrinogen, which is essential for physiological homeostasis. It is involved in various disorders such as thrombosis and disseminated intravascular coagulation.
Check Digit Verification of cas no
The CAS Registry Mumber 103213-49-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,2,1 and 3 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 103213-49:
(8*1)+(7*0)+(6*3)+(5*2)+(4*1)+(3*3)+(2*4)+(1*9)=66
66 % 10 = 6
So 103213-49-6 is a valid CAS Registry Number.
InChI:InChI=1/C66H95N19O26/c1-31(2)53(85-48(90)29-73-55(100)35(67)16-19-49(91)92)64(109)83-42(26-46(69)88)61(106)82-43(27-52(97)98)62(107)81-41(25-45(68)87)60(105)78-37(18-21-51(95)96)57(102)77-36(17-20-50(93)94)56(101)74-28-47(89)76-39(23-33-11-6-4-7-12-33)58(103)80-40(24-34-13-8-5-9-14-34)59(104)84-44(30-86)63(108)75-32(3)54(99)79-38(65(110)111)15-10-22-72-66(70)71/h4-9,11-14,31-32,35-44,53,86H,10,15-30,67H2,1-3H3,(H2,68,87)(H2,69,88)(H,73,100)(H,74,101)(H,75,108)(H,76,89)(H,77,102)(H,78,105)(H,79,99)(H,80,103)(H,81,107)(H,82,106)(H,83,109)(H,84,104)(H,85,90)(H,91,92)(H,93,94)(H,95,96)(H,97,98)(H,110,111)(H4,70,71,72)
