103224-70-0Relevant articles and documents
Regioselective Side-Chain Nitration of Polymethylbenzenes Directed by an Acyl Function and Its Application to the Synthesis of Polysubstituted Phthalic Acid Derivatives
Keumi, Takashi,Morita, Toshio,Teramoto, Koichi,Takahashi, Hisakazu,Yamamoto, Hiroshi,et al.
, p. 3439 - 3446 (2007/10/02)
Nitration of three types of tetramethylacetophenones and pentamethylacetophenone with fuming nitric acid in acetic anhydride was carried out.The product distributions were compared with those estimated from substituent effects.A variety of acylpentamethylbenzenes including pentamethylbenzoic acid were reacted with the nitrating system to give regioselectively 2-(nitromethyl)-3,4,5,6-tetramethylacylbenzenes.The selective nitrations of some benzoic acid derivatives followed by an alkaline treatment have been found to provide the N-hydroxyphthalimide derivatives, which a re readily converted to the phthalic anhydrides and the phthalazines.