1032509-63-9

Basic information

• Product Name: 1-(2-(methoxymethoxy)ethyl)-2-methylbenzene
• Synonyms: 1-(2-(methoxymethoxy)ethyl)-2-methylbenzene
• CAS NO: 1032509-63-9
• Molecular Weight: 180.247
• Mol File: 1032509-63-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-(2-(methoxymethoxy)ethyl)-2-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-(methoxymethoxy)ethyl)-2-methylbenzene(1032509-63-9)
• EPA Substance Registry System: 1-(2-(methoxymethoxy)ethyl)-2-methylbenzene(1032509-63-9)

Safety Data

• Hazardous Substances Data: 1032509-63-9(Hazardous Substances Data)

Upstream product

• 19819-98-8 2-o-tolylethanol 
• 107-30-2 chloromethyl methyl ether 
• 109-87-5 Dimethoxymethane 
• 644-36-0 o-methylphenylacetic acid 

Downstream Products

• 1338236-47-7 C₁₉H₁₈O 
• 1219468-13-9 N-benzoylimino-3,4-dihydro-5-methylisoquinolinium betaine 
• 1219468-04-8 2-(2-bromoethyl)-3-methylbenzaldehyde 

Relevant articles and documents

Enantioselective synthesis of tetrahydroisoquinoline derivatives via chiral-at-metal rhodium complex catalyzed [3+2] cycloaddition

An asymmetric [3+2] cycloaddition of C,N-cyclic azomethine imines with α,β-unsaturated 2-acyl imidazoles catalyzed by a chiral-at-metal rhodium complex has been developed. The corresponding C-1-substituted tetrahydroisoquinoline derivatives were obtained in high yields (>90%) with excellent stereoselectivities (up to 99% ee and >20?:?1 dr). The reaction can be conducted on a gram-scale using a low catalyst loading (0.5 mol%) with high yield and selectivity.

Synthesis of 5,6-Dihydropyrazolo[5,1-a]isoquinoline and Ethyl (Z)-3-Acetoxy-3-tosylpent-4-enoate through Tertiary-Amine-Catalyzed [3+2] Annulation

The 1,4-diazabicyclo[2.2.2]octane (DABCO) catalyzed divergent [3+2] annulation of C,N-cyclic azomethine imines with δ-acetoxyallenoates was developed; 5,6-dihydropyrazolo[5,1-a]isoquinolines and ethyl (Z)-3-acetoxy-3-tosylpent-4-enoates were afforded in moderate to good yields in a one-pot manner under mild conditions. This annulation reaction provides a highly efficient method to construct dinitrogen-fused heterocycles and ethyl (Z)-3-acetoxy-3-tosylpent-4-enoates at the same time.

A Phosphine-Catalyzed Novel Asymmetric [3+2] Cycloaddition of C,N-Cyclic Azomethine Imines with δ-Substituted Allenoates

Catalytic asymmetric [3+2] cycloadditions of C,N-cyclic azomethine imines with δ-substituted allenoates have been developed in the presence of (S)-Me-f-KetalPhos, affording functionalized tetrahydroquinoline frameworks in good yields with high diastereo- and good enantioselectivities under mild condition. The substrate scope has been also examined. This is the first time that δ-substituted allenoates have been applied as a δ,γ-C-C bond participated C 2 synthon in asymmetric synthesis. Another round: Catalytic asymmetric [3+2] cycloaddition of C,N-cyclic azomethine imines with δ-substituted allenoates have been developed in the presence of (S)-Me-f-KetalPhos, affording functionalized tetrahydroquinoline frameworks in good yields with high diastereo- and good enantioselectivities under mild conditions. This is the first example applying δ-substituted allenoates as C 2 synthons in asymmetric δ,γ-C-C bond formation.