1032568-63-0 Usage
Description
BAY 80-6946 (Copanlisib) is a highly selective intravenous PI3K inhibitor that demonstrates potent p110α and p110δ activities in tumor cell lines and xenograft models. It is a pharmaceutical compound designed to target and inhibit the PI3K enzyme, which plays a crucial role in cell growth and survival, and is often dysregulated in various types of cancer.
Uses
Used in Oncology:
BAY 80-6946 (Copanlisib) is used as an anticancer agent for the treatment of various malignancies. It targets the PI3K enzyme, which is frequently overactive in cancer cells, leading to uncontrolled cell growth and proliferation. By inhibiting this enzyme, Copanlisib aims to slow down or stop tumor growth, making it a promising therapeutic option for patients with certain types of cancer.
Used in Drug Development:
In the pharmaceutical industry, BAY 80-6946 (Copanlisib) serves as a key compound in the development of novel cancer treatments. Its potent and selective inhibition of the PI3K enzyme makes it a valuable asset in the search for more effective and targeted therapies for cancer patients. Researchers and drug developers utilize Copanlisib to study its potential synergistic effects with other cancer-fighting agents and to explore its role in combination therapies.
Used in Clinical Trials:
BAY 80-6946 (Copanlisib) is also used in clinical trials to evaluate its safety, efficacy, and optimal dosing regimens for various types of cancer. These trials are essential in determining the potential benefits and risks associated with the use of Copanlisib as a cancer treatment, ultimately guiding its approval and integration into standard cancer care practices.
Check Digit Verification of cas no
The CAS Registry Mumber 1032568-63-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,2,5,6 and 8 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1032568-63:
(9*1)+(8*0)+(7*3)+(6*2)+(5*5)+(4*6)+(3*8)+(2*6)+(1*3)=130
130 % 10 = 0
So 1032568-63-0 is a valid CAS Registry Number.
1032568-63-0Relevant articles and documents
A preparation method of the storehouse pan nixi
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, (2018/01/11)
The invention discloses a preparation method of copanlisib (BAY80-6946). The target compound copanlisib is prepared by a known raw material 2-amino-3-methoxyl-4-(3-morpholine-4-propoxy) cyanophenyl by virtue of reactions such as heterocyclization, amidation, substitution-cyclization and the like. The preparation method is novel in route design, easy for obtaining the raw material, simple in process, economical, environment-friendly and suitable for industrialized production.
SYNTHESIS OF COPANLISIB AND ITS DIHYDROCHLORIDE SALT
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Page/Page column 37, (2016/06/01)
The present invention relates to a novel method of preparing copanlisib, and copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said copanlisib.
Combinations of substituted 2,3-dihydroimidazo[1,2-c]quinazolines
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, (2010/04/25)
The present invention relates to the use of 2,3-dihydroimidazo[1,2-c]quinazoline compounds, and of pharmaceutical compositions containing such compounds, for the treatment or prophylaxis of multiple myeloma, as a sole agent or in combination with other one or more other active ingredients.
