1032818-02-2

Basic information

• Product Name: 3-cyclopropyl-5-phenyloxazolidin-2-one
• Synonyms: 3-cyclopropyl-5-phenyloxazolidin-2-one
• CAS NO: 1032818-02-2
• Molecular Weight: 203.241
• Mol File: 1032818-02-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-cyclopropyl-5-phenyloxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-cyclopropyl-5-phenyloxazolidin-2-one(1032818-02-2)
• EPA Substance Registry System: 3-cyclopropyl-5-phenyloxazolidin-2-one(1032818-02-2)

Safety Data

• Hazardous Substances Data: 1032818-02-2(Hazardous Substances Data)

Upstream product

• 96-09-3 styrene oxide 
• 102-09-0 bis(phenyl) carbonate 
• 4917-70-8 2-(cyclopropylamino)-1-phenylethanol 
• 75326-15-7 (2-bromo-1-phenylethyl)dimethylsulphonium bromide 
• 100-42-5 styrene 
• 1032817-95-0 1-cyclopropyl-2-phenylaziridine 
• 124-38-9 carbon dioxide 

Relevant articles and documents

Synthesis of Oxazolidinones by using Carbon Dioxide as a C1 Building Block and an Aluminium-Based Catalyst

Oxazolidinone synthesis through the coupling of carbon dioxide and aziridines was catalysed by an aluminium(salphen) complex at 50–100 °C and 1–10 bar pressure under solvent-free conditions. The process was applicable to a variety of substituted aziridines, giving products with high regioselectivity. It involved the use of a sustainable and reusable aluminium-based catalyst, used carbon dioxide as a C1 source and provided access to pharmaceutically important oxazolidinones as illustrated by a total synthesis of toloxatone. This protocol was scalable, and the catalyst could be recovered and reused. A catalytic cycle was proposed based on stereochemical, kinetic and Hammett studies.

Synthesis of chiral oxazolidinone derivatives through lipase-catalyzed kinetic resolution

The synthesis of enantioenriched oxazolidinone derivatives through lipase-catalyzed kinetic resolution is described. The synthesis comprised a two-step, cascade acylation in one pot, resulting in a range of oxazolidinone derivatives in good yields and exc

Lewis basic ionic liquids-catalyzed synthesis of 5-aryl-2-oxazolidinones from aziridines and CO2 under solvent-free conditions

A series of easily prepared Lewis basic ionic liquids were developed as recyclable and efficient catalysts for selective synthesis of 5-aryl-2-oxazolidinones from aziridines and CO2 without utilization of any organic solvent or additive. Notably, high conversion, chemo- and regio-selectivity were attained when 1-butyl-4-aza-1-azaniabicyclo[2.2.2]octane bromide ([C4DABCO]Br) was used as the catalyst. Furthermore, the catalyst could be recycled over four times without appreciable loss of catalytic activity. The effects of the catalyst structure and various reaction parameters on the catalytic performance were investigated in detail. This protocol was found to be applicable to a variety of aziridines producing the corresponding 5-aryl-2-oxazolidinones in good yields and excellent regioselectivities. Therefore, this solvent-free process thus represents an environmentally friendly process for ionic liquid-catalyzed conversion of CO2 into value-added chemicals. A possible catalytic cycle for CO2 activation induced by nucleophilic tertiary nitrogen of the ionic liquid was proposed, based on studies using in situ FT-IR spectroscopy under CO2 pressure.