103293-58-9

Basic information

• Product Name: 5-Pyrimidinecarboxylic acid, 4-(4-hydroxy-3-nitrophenyl)-6-methyl-2-phenyl-, ethyl ester
• CAS NO: 103293-58-9
• Molecular Formula: C20H17N3O5
• Molecular Weight: 379.372
• Mol File: 103293-58-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinecarboxylic acid, 4-(4-hydroxy-3-nitrophenyl)-6-methyl-2-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylic acid, 4-(4-hydroxy-3-nitrophenyl)-6-methyl-2-phenyl-, ethyl ester(103293-58-9)
• EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 4-(4-hydroxy-3-nitrophenyl)-6-methyl-2-phenyl-, ethyl ester(103293-58-9)

Safety Data

• Hazardous Substances Data: 103293-58-9(Hazardous Substances Data)

Upstream product

• 103293-32-9 2-[1-(4-Hydroxy-3-nitro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid ethyl ester 
• 141-97-9 ethyl acetoacetate 
• 1670-14-0 benzamidine monohydrochloride 
• 3011-34-5 4-hydroxy-3-nitrobenzaldehyde 
• 103311-53-1 4-(4-Hydroxy-3-nitro-phenyl)-6-methyl-2-phenyl-1,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 103293-89-6 ethyl 4-(4-acetoxy-3-nitrophenyl)-6-methyl-2-phenyl-5-pyrimidinecaboxylate 

Relevant articles and documents

Studies on cerebral protective agents. I. Novel 4-arylpyrimidine derivatives with anti-anoxic and anti-lipid peroxidation activities

Novel 4-arylpyrimidine derivatives were synthesized by the oxidation of 4-aryl-1,4-dihydropyrimidines, and their effects on anti-anoxic (AA) activity in mice and anti-lipid peroxidation (ALP) activity in rat brain mitochondria were investigated. Among these compounds, ethyl 6-methyl-2-phenyl-4-(4-pyridyl)-5-pyrimidinecarboxylate (4b) has AA activity (10mg/kg, i.p.) and ethyl 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylate (4f) has ALP activity (73% inhibition at 10-5 g/ml). The latter compound (100mg/kg, i.p.) was also effective on arachidonate-induced cerebral edema in rats with comparable potency to that of vitamin E.