1033280-93-1Relevant articles and documents
Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: Structure-activity relationships and mode of action studies
Masci, Domiziana,Hind, Charlotte,Islam, Mohammad K.,Toscani, Anita,Clifford, Melanie,Coluccia, Antonio,Conforti, Irene,Touitou, Meir,Memdouh, Siham,Wei, Xumin,La Regina, Giuseppe,Silvestri, Romano,Sutton, J. Mark,Castagnolo, Daniele
, p. 500 - 514 (2019/06/18)
Antibiotic resistance represents a major threat worldwide. Gram-positive and Gram-negative opportunistic pathogens are becoming resistant to all known drugs mainly because of the overuse and misuse of these medications and the lack of new antibiotic development by the pharmaceutical industry. There is an urgent need to discover structurally innovative antibacterial agents for which no pre-existing resistance is known. This work describes the identification, synthesis and biological evaluation of a novel series of 1,5-diphenylpyrrole compounds active against a panel of ESKAPE bacteria. The new compounds show high activity against both wild type and drug-resistant Gram + ve and Gram-ve pathogens at concentrations similar or lower than levofloxacin. Microbiology studies revealed that the plausible target of the pyrrole derivatives is the bacterial DNA gyrase, with the pyrrole derivatives displaying similar inhibitory activity to levofloxacin against the wild type enzyme and retaining activity against the fluoroquinolone-resistant enzyme.
Anti-tubercular agents. Part 7: A new class of diarylpyrrole-oxazolidinone conjugates as antimycobacterial agents
Kamal, Ahmed,Swapna,Shetti, Rajesh V.C.R.N.C.,Shaik, Anver Basha,Narasimha Rao,Sultana, Farheen,Khan, Inshad Ali,Sharma, Sandeep,Kalia, Nitin Pal,Kumar, Sunil,Chandrakant, Bagul
, p. 239 - 251 (2013/07/27)
In an effort to discover new anti-tubercular agents, a series of new diarylpyrrole-oxazolidinone conjugates have been designed and synthesized. The anti-tubercular activity of these new conjugates (4a-n and 5a-d) against Mycobacterium tuberculosis H3
1,5-Diphenylpyrrole derivatives as antimycobacterial agents. Probing the influence on antimycobacterial activity of lipophilic substituents at the phenyl rings
Biava, Mariangela,Porretta, Giulio Cesare,Poce, Giovanna,De Logu, Alessandro,Saddi, Manuela,Meleddu, Rita,Manetti, Fabrizio,De Rossi, Edda,Botta, Maurizio
supporting information; experimental part, p. 3644 - 3648 (2009/04/07)
Synthesis and biological evaluation of new derivatives of 1,5-bis(4-chlorophenyl)-2-methyl-3-(4-methylpiperazin-1-yl)methyl-1H-pyrrole (BM 212, 16) are reported. Variously substituted phenyl rings with different substitution pattern and lipophilicity were