10333-86-5Relevant articles and documents
A NOVEL AND EFFICIENT SYNTHESIS OF ISOGUANOSINE
Chern, Ji-Wang,Lee, Horng-Yuh,Huang, Min,Shish, Fang-Jy
, p. 2151 - 2154 (1987)
Isoguanosine (4b) was synthesized by a one-pot reaction involving a condensation of 5-amino-1-(β-D-ribofuranosyl)imidazole-4-carboxamide (1b) with benzoyl isothiocyanate, treatment of the resulting thiourea derivative with DCC furnished 5-(N1-benzoylcarbamoyl)aminoimidazole-4-carbonitrile (3b) which was then annulated with ethanolic ammonia to afford isoguanosine in a 68percent yield from 1b.