1033735-94-2 Usage
General Description
GNE-493 is a potent, dual pan-phosphoinositide 3-kinase/mammalian target of rapamycin (PI3K/mTOR) inhibitor. In the medical and scientific research fields, it is used as an experimental compound for its potential anticancer activities. It functions by blocking the PI3K/mTOR pathway, a pathway that is critical for cell growth and proliferation, therefore, inhibiting the growth of cancer cells. However,
Check Digit Verification of cas no
The CAS Registry Mumber 1033735-94-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,3,7,3 and 5 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1033735-94:
(9*1)+(8*0)+(7*3)+(6*3)+(5*7)+(4*3)+(3*5)+(2*9)+(1*4)=132
132 % 10 = 2
So 1033735-94-2 is a valid CAS Registry Number.
InChI:InChI=1S/C17H20N6O2S/c1-17(2,24)12-7-11-13(26-12)15(23-3-5-25-6-4-23)22-14(21-11)10-8-19-16(18)20-9-10/h7-9,24H,3-6H2,1-2H3,(H2,18,19,20)
1033735-94-2Relevant articles and documents
Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available Pan-PI3-kinase and dual Pan-PI3-kinase/mTOR inhibitors for the treatment of cancer
Sutherlin, Daniel P.,Sampath, Deepak,Berry, Megan,Castanedo, Georgette,Chang, Zhigang,Chuckowree, Irina,Dotson, Jenna,Folkes, Adrian,Friedman, Lori,Goldsmith, Richard,Heffron, Tim,Lee, Leslie,Lesnick, John,Lewis, Cristina,Mathieu, Simon,Nonomiya, Jim,Olivero, Alan,Pang, Jodie,Prior, Wei Wei,Salphati, Laurent,Sideris, Steve,Tian, Qingping,Tsui, Vickie,Wan, Nan Chi,Wang, Shumei,Wiesmann, Christian,Wong, Susan,Zhu, Bing-Yan
experimental part, p. 1086 - 1097 (2010/08/05)
The PI3K/AKT/mTOR pathway has been shown to play an important role in cancer. Starting with compounds 1 and 2 (GDC-0941) as templates, (thienopyrimidin-2-yl)aminopyrimidines were discovered as potent inhibitors of PI3K or both PI3K and mTOR. Structural in
