10338-34-8

Basic information

• Product Name: (3beta,5beta,6beta)-3-hydroxy-5,6-epoxyandrostan-17-one
• Synonyms: (3beta,5beta,6beta)-3-Hydroxy-5,6-epoxyandrostan-17-one; (3beta,5beta,6beta)-5,6-Epoxy-3-hydroxyandrostan-17-one; androstan-17-one, 5,6-epoxy-3-hydroxy-, (3beta,5beta,6beta)-
• CAS NO: 10338-34-8
• Molecular Formula: C₁₉H₂₈O₃
• Molecular Weight: 304.4238
• Mol File: 10338-34-8.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 451°C at 760 mmHg
• Flash Point: 160.1°C
• Density: 1.2g/cm³
• Vapor Pressure: 4.96E-10mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: (3beta,5beta,6beta)-3-hydroxy-5,6-epoxyandrostan-17-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3beta,5beta,6beta)-3-hydroxy-5,6-epoxyandrostan-17-one(10338-34-8)
• EPA Substance Registry System: (3beta,5beta,6beta)-3-hydroxy-5,6-epoxyandrostan-17-one(10338-34-8)

Safety Data

• Hazardous Substances Data: 10338-34-8(Hazardous Substances Data)

Upstream product

• 53-43-0 dehydroepiandrosterone 
• 108-05-4 vinyl acetate 

Relevant articles and documents

Microbiological hydroxylation of some epoxy steroids by the fungus Mucor plumbeus

The preparation of epoxy steroids derived from testosterone, dehydroisoandrosterone and epiandrosterone using m-chloroperbenzoic acid and their biotransformation by the fungus Mucor plumbeus is described. The results reveal an effect of the epoxide on the biotransformation.

Chemoselective epoxidation of cholesterol derivatives on a surface-designed molecularly imprinted Ru-porphyrin catalyst

A new molecularly imprinted Ru-porphyrin complex catalyst on a SiO2 support was designed, prepared, and characterized in a step-by-step manner for the C5C6 epoxidation of cholesterol derivatives. High chemoselectivity for the C5C6 epoxidation of cholesterol derivatives without protecting the 3-position OH group and other oxidizable functional groups was achieved on the molecularly imprinted catalyst.

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Poly(per)fluoroalkanesulfonyl fluoride promoted olefin epoxidation with 30% aqueous hydrogen peroxide

Epoxidation of various electron rich olefins with a novel oxidation system of poly(per)fluoroalkanesulfonyl fluoride/hydrogen peroxide/base is reported.

AMINO DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS

Compounds of formula (I) wherein:the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+,K+-ATPase. Said compounds are used for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.