1033809-85-6

Basic information

• Product Name: 1H-Isoindol-1-one,2,3-dihydro-7-hydroxy-
• Synonyms: 1H-Isoindol-1-one,2,3-dihydro-7-hydroxy-;2,3-dihydro-7-hydroxy-1H-Isoindol-1-one;7-Hydroxy-2,3-dihydro-1H-isoindol-1-one;7-Hydroxy-2,3-dihydroisoindol-1-one
• CAS NO: 1033809-85-6
• Molecular Formula: C₈H₇NO₂
• Molecular Weight: 149.14668
• Mol File: 1033809-85-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-Isoindol-1-one,2,3-dihydro-7-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindol-1-one,2,3-dihydro-7-hydroxy-(1033809-85-6)
• EPA Substance Registry System: 1H-Isoindol-1-one,2,3-dihydro-7-hydroxy-(1033809-85-6)

Safety Data

• Hazardous Substances Data: 1033809-85-6(Hazardous Substances Data)

Usage

General Description

The chemical 1H-Isoindol-1-one, 2,3-dihydro-7-hydroxy- is a compound with the molecular formula C8H7NO2. It is a derivative of isoindoline and belongs to the class of organic compounds known as isoindoles. 1H-Isoindol-1-one,2,3-dihydro-7-hydroxy- has a white solid appearance and is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. Its chemical structure contains a ring system with a hydroxy group, making it a potential candidate for various biological activities and medicinal uses. Further research and testing are needed to better understand its potential applications and properties.

Upstream product

• 808127-81-3 4-bromo-7-hydroxy-2,3-dihydro-1H-isoindol-1-one 
• 808127-82-4 4-bromo-7-methoxy-2,3-dihydro-1H-isoindol-1-one 
• 6520-83-8 ethyl 2-methoxy-6-methylbenzoate 
• 133379-05-2 ethyl 3-bromo-2-(bromomethyl)-6-methoxybenzoate 

Downstream Products

• 1033809-87-8 7-(4-amino-2-chlorophenoxy)-2,3-dihydro-1H-isoindol-1-one 
• 1033809-86-7 7-(2-chloro-4-nitrophenoxy)-2,3-dihydro-1H-isoindol-1-one 

Relevant articles and documents

Design and synthesis of pyrrolo[3,2- d ]pyrimidine human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors: Exploration of novel back-pocket binders

To develop novel human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) kinase inhibitors, we explored pyrrolo[3,2-d]pyrimidine derivatives bearing bicyclic fused rings designed to fit the back pocket of the HER2/EGFR proteins. Among them, the 1,2-benzisothiazole (42m) ring was selected as a suitable back pocket binder because of its potent HER2/EGFR binding and cell growth inhibitory (GI) activities and pseudoirreversibility (PI) profile as well as good bioavailability (BA). Ultimately, we arrived at our preclinical candidate 51m by optimization of the N-5 side chain to improve CYP inhibition and metabolic stability profiles without a loss of potency (HER2/EGFR inhibitory activity, IC50, 0.98/2.5 nM; and GI activity BT-474 cells, GI50, 2.0 nM). Reflecting the strong in vitro activities, 51m exhibited potent tumor regressive efficacy against both HER2- and EGFR-overexpressing tumor (4-1ST and CAL27) xenograft models in mice at oral doses of 50 mg/kg and 100 mg/kg.