1034297-69-2 Usage
Description
6-Methoxypyridine-2-boronic acid pinacol ester is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals and bioactive molecules. It is characterized by its boronic acid functionality and pinacol ester group, which play crucial roles in its reactivity and applications.
Uses
Used in Pharmaceutical Industry:
6-Methoxypyridine-2-boronic acid pinacol ester is used as an active pharmaceutical intermediate for the synthesis of various drugs and therapeutic agents. Its unique chemical structure allows for the development of novel compounds with potential applications in treating different diseases and medical conditions.
Used in Medicinal Chemistry Research:
6-Methoxypyridine-2-boronic acid pinacol ester is employed in the design and structure-activity relationship studies of new bioactive molecules. Its versatile reactivity enables the creation of diverse chemical libraries, which can be screened for potential drug candidates.
Used in Drug Development:
6-Methoxypyridine-2-boronic acid pinacol ester is utilized in the in vivo characterization of development candidate nvp-hsp990. Its incorporation into the candidate molecule allows for the evaluation of its pharmacological properties, safety, and efficacy in preclinical and clinical studies.
Check Digit Verification of cas no
The CAS Registry Mumber 1034297-69-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,4,2,9 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1034297-69:
(9*1)+(8*0)+(7*3)+(6*4)+(5*2)+(4*9)+(3*7)+(2*6)+(1*9)=142
142 % 10 = 2
So 1034297-69-2 is a valid CAS Registry Number.
1034297-69-2Relevant articles and documents
Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS)
Edfeldt, Fredrik,Even?s, Johan,Lepist?, Matti,Ward, Alison,Petersen, Jens,Wissler, Lisa,Rohman, Mattias,Sivars, Ulf,Svensson, Karin,Perry, Matthew,Feierberg, Isabella,Zhou, Xiao-Hong,Hansson, Thomas,Narjes, Frank
, p. 2496 - 2500 (2015)
Abstract Human H-PGDS has shown promise as a potential target for anti-allergic and anti-inflammatory drugs. Here we describe the discovery of a novel class of indole inhibitors, identified through focused screening of 42,000 compounds and evaluated using a series of hit validation assays that included fluorescence polarization binding, 1D NMR, ITC and chromogenic enzymatic assays. Compounds with low nanomolar potency, favorable physico-chemical properties and inhibitory activity in human mast cells have been identified. In addition, our studies suggest that the active site of hH-PGDS can accommodate larger structural diversity than previously thought, such as the introduction of polar groups in the inner part of the binding pocket.
