103475-41-8 Usage
Description
Tepoxalin is a hydroxamic acid derived from the formal condensation of the carboxy group of 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]propanoic acid with the amino group of N-methylhydroxylamine. It is a non-steroidal anti-inflammatory drug (NSAID) with potent anti-inflammatory and analgesic properties, primarily used in veterinary medicine.
Used in Veterinary Medicine:
Tepoxalin is used as an anti-inflammatory and analgesic agent for the control of pain and inflammation caused by musculoskeletal disorders such as hip dysplasia and arthritis in dogs. Its mechanism of action involves the inhibition of cyclooxygenase and 5-lipxygenase activity, as well as the suppression of cytokine production in peripheral cells outside the central nervous system.
Chemical Properties:
Tepoxalin is an off-white solid with potent anti-inflammatory and analgesic properties, making it a valuable compound in the treatment of various musculoskeletal disorders in veterinary medicine.
Veterinary Drugs and Treatments
Tepoxalin is indicated for the treatment of pain and inflammation
associated with osteoarthritis in dogs. Because of the drug’s inhibitory
effects on leukotrienes, there is interest in seeing if it would
be beneficial in the adjunctive treatment of allergic conditions in
dogs.
Check Digit Verification of cas no
The CAS Registry Mumber 103475-41-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,4,7 and 5 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 103475-41:
(8*1)+(7*0)+(6*3)+(5*4)+(4*7)+(3*5)+(2*4)+(1*1)=98
98 % 10 = 8
So 103475-41-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H20ClN3O3/c1-23(26)20(25)12-7-16-13-19(14-3-5-15(21)6-4-14)24(22-16)17-8-10-18(27-2)11-9-17/h3-6,8-11,13,26H,7,12H2,1-2H3
103475-41-8Relevant articles and documents
Process for preparing 1,5-diaryl-3-substituted pyrazoles
-
, (2008/06/13)
A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III which is reacted with a compound of formula IV to form a compound of V and reacting with an alcohol to form the corresponding ester of formula VI and reacting the ester with N-methylhydroxylamine.
N-hydroxy, N-methyl propanamides
-
, (2008/06/13)
The invention provides a process for preparing 1,5-diaryl pyrazole anti-inflammatory agents. A 6-aryl-4,6-dioxohexanoic acid is treated with acetic anhydride or acetyl chloride to produce an enol lactone, which is added to methylhydroxylamine to generate the dione hydroxamic acid. This dione hydroxamic acid is then treated with 4-methoxyphenylhydrazine hydrochloride to yield the 1,5-diaryl pyrazole. Novel intermediate compounds in the synthetic pathway are also disclosed.
Regioselective synthesis of a 1,5-disubstituted pyrazole
-
, (2008/06/13)
A highly regioselective synthesis of pyrazoles from a mono-substituted hydrazine and a β-dicarbonyl compound wherein a carboxylic acid moiety is present on the substituent attached to one of the carbonyls. For example, compounds of the formula (I) are formed in marked preference to isomers of formula (IV): STR1