1034767-23-1

Basic information

• Product Name: 4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-one
• Synonyms: 4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-one
• CAS NO: 1034767-23-1
• Molecular Weight: 239.274
• Mol File: 1034767-23-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-one(1034767-23-1)
• EPA Substance Registry System: 4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-one(1034767-23-1)

Safety Data

• Hazardous Substances Data: 1034767-23-1(Hazardous Substances Data)

Upstream product

• 98554-71-3 3,4-dihydro-2H-1,4-benzoxazin-2-one 
• 100-52-7 benzaldehyde 
• 95-55-6 2-amino-phenol 
• 99450-18-7 N-(2-hydroxyphenyl)glycine ethyl ester 

Downstream Products

• 98554-71-3 3,4-dihydro-2H-1,4-benzoxazin-2-one 
• 1034767-22-0 2-(2-hydroxyphenylamino)-N,N-dimethylacetamide 
• 5543-37-3 cephalandole A 

Relevant articles and documents

[Omim]Cl/FeCl3-catalyzed cross-dehydrogenative-coupling of 1,4-benzoxazinones with various indoles

A novel C(sp3)–C(sp2) cross-dehydrogenative-coupling procedure was developed for the reaction of benzoxazin-2-ones with indole derivatives. Thus, ionic liquid-mediated coupling of 1,4-benzoxazinone derivatives with indoles were observed in which [Omim]Cl/FeCl3 acted as both the solvent and the catalyst. Under [Omim]Cl/FeCl3-TBHP conditions, derivatives of 1 coupled at room temperature with indoles bearing various substituents to give the target products in good yields and within 0.5–2?h time period. The procedure is relatively environmentally friendly and is applicable to several derivatives of both reactants to access the desired products.

A convenient synthesis of 3,4-dihydro-1,4-benzoxazin-2-ones

3,4-Dihydro-1,4-benzoxazin-2-one was prepared for the first time by catalytic hydrogenation of 4-benzyl-3,4-dihydro-1,4-benzoxazin-2-one. A simple and efficient synthesis of 4-benzyl- and 4-alkyl-3,4-dihydro-1,4-benzoxazin-2-one derivatives from ethyl 2-(2-hydroxyphenylamino)acetate and aldehydes is described. Some considerations regarding the reactivity of 3,4-dihydro-1,4-benzoxazin-2-ones are given.