1035347-03-5Relevant articles and documents
Selective C4-F bond cleavage of pentafluorobenzene: Synthesis of N-tetrafluoroarylated heterocyclic compounds
Liu, Cuibo,Wang, Huan,Xing, Xing,Xu, You,Ma, Jun-An,Zhang, Bin
, p. 4649 - 4652 (2013)
A simple aromatic nucleophilic monosubstitution reaction for the synthesis of N-tetrafluoroarylated heterocyclic compounds via selective C4-F bond cleavage of pentafluorobenzene with N-H containing heterocycles is demonstrated. This method is highly tolerant of a wide range of substrates to give the corresponding products in moderate to good yields. Additionally, this strategy is applied to synthesize other mono-, di-, and tri-fluoroarylated indole derivatives. Crown Copyright