10354-47-9

Basic information

• Product Name: N-cyclohexylfuran-2-carboxamide
• Synonyms: 2-furancarboxamide, N-cyclohexyl-; N-Cyclohexyl-2-furamide
• CAS NO: 10354-47-9
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.2423
• Mol File: 10354-47-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 370.9°C at 760 mmHg
• Flash Point: 178.1°C
• Density: 1.11g/cm³
• Vapor Pressure: 1.07E-05mmHg at 25°C
• Refractive Index: 1.525
• CAS DataBase Reference: N-cyclohexylfuran-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexylfuran-2-carboxamide(10354-47-9)
• EPA Substance Registry System: N-cyclohexylfuran-2-carboxamide(10354-47-9)

Safety Data

• Hazardous Substances Data: 10354-47-9(Hazardous Substances Data)

Upstream product

• 54829-48-0 2-iodofuran 
• 201230-82-2 carbon monoxide 
• 108-91-8 cyclohexylamine 
• 527-69-5 2-furancarbonyl chloride 
• 144223-33-6 2-furoyl-1H-1,2,3-benzotriazole 
• 609-38-1 furan-2-carboxylic acid amide 
• 626-62-0 Cyclohexyl iodide 
• 88-14-2 2-furanoic acid 
• 58777-49-4 2-furoyl bromide 

Downstream Products

• 126265-85-8 N-cyclohexylfuran-2-carbothioamide 
• 876893-30-0 N-[(1H-1,2,3-benzotriazol-1-yl)(2-furyl)methylidene]-N-cyclohexylamine 
• 220717-32-8 N-Cyclohexyl-5-carbamoylfuran-2-sulfonic Acid Sodium Salt 

Relevant articles and documents

Integration of co2 reduction with subsequent carbonylation: Towards extending chemical utilization of co2

Currently, it still remains a challenge to amplify the spectrum of chemical fixation of CO2, although enormous progress has been achieved in this field. In view of the widespread applications of CO in a myriad of industrial carbonylation processes, an alternative strategy is proposed in which CO2 reduction to CO is combined with carbonylation with CO generated ex situ, which affords efficiently pharmaceutically and agrochemically attractive molecules. As such, CO2 in this study was efficiently reduced by triphenysilane using CsF to CO in a sealed two-chamber reactor. Subsequently, palladium-catalyzed aminocar-bonylation, carbonylative Sonogashira coupling of aryl iodides, and rhodium(I)-mediated Pauson–Khand-type reaction proceeded smoothly to yield amides, alkynones, and bicyclic cy-clopentenones, respectively. Furthermore, the formed alkynones can further be successfully converted to a series of heterocycles, for example, pyrazoles, 3a-hydroxyisoxazolo[3,2-a]isoindol-8-(3aH)-one derivatives and pyrimidines in moderate yields. The striking features of this protocol include operational simplicity, high efficiency, and relatively broad application scope, which represents an alternative avenue for CO2 transformation.

A mild and efficient reaction for conversion of carboxylic acids into acid bromides with ethyl tribromoacetate/triphenylphosphine under acid-free conditions

Acid bromides were prepared efficiently from carboxylic acids with readily available ethyl tribromoacetate and triphenylphosphine at room temperature under neutral conditions. The present process is applicable to the preparation of various acid bromides from aromatic and aliphatic carboxylic acids. Aromatic carboxylic acids were found to be more reactive than aliphatic carboxylic acids under reaction conditions.

Determination of aromaticity indices of thiophene and furan by nuclear magnetic resonance spectroscopic analysis of their anilides

A series of m- and p-substituted anilides of benzoic acid, 2-thienoic acid, and 2-furoic acid were prepared and their 1H and 13C nmr spectroscopic characteristics were examined. In general, good correlations were observed between the chemical shifts of proton and carbon signals of the acyl aromatic rings and the Hammett σ. Plots of the chemical shift values of the carbonyl carbons of the benzanilides against those of the 2-thienamides and 2-furamides gave an excellent correlation and the values of the slopes are 0.79 and 0.52, respectively, in dimethyl sulfoxide-d6. The slopes could be considered as a set of aromaticity index.