103577-61-3Relevant articles and documents
Safety evaluation of an unexpected incident with a nitro compound
Barbas, Rafael,Botija, Manuel,Camps, Helena,Portell, Anna,Prohens, Rafel,Puigjaner, Cristina
, p. 1131 - 1134 (2007)
An unexpected highly exothermic reaction followed by explosion has been studied by means of reaction calorimetry and adiabatic calorimetry. The investigation of the process shows that the incident took place by a local adiabatic temperature rise in the reactor vessel due to the presence of potassium carbonate, which activated the decomposition of a nitro compound with an unusual low temperature onset The study is completed with an unproved and safer procedure consisting of changing the order of chemicals addition as an alternative approach.
Diversified synthesis of novel quinoline and dibenzo thiazepine derivatives using known active intermediates
Sharada,Satyanarayana Reddy,Sammaiah,Sumalatha
, p. 7959 - 7966 (2013/09/23)
The novel drug development to control resisting infections in conventional drug therapy is a need of today. Few antiulcer relative derivatives developed by approaching convergent synthesis. The derivatives synthesized successfully are dibenzo thiazepine-pyridine (SLN11-SLN15) and benzimidazole-hydroquinoline based derivatives (SLN16-SLN20). It involved the coupling through microwave, sonication and conventional techniques at final step. The efficient technology identified as sonication technique basically time and yield. The reported compounds were structural characterized by elemental analysis and spectral studies such as 1H, 13C NMR and MS.
Crystals of benzimidazole derivatives and their production
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, (2008/06/13)
A substantially solvent-free and stable crystal of the compound of the formula: STR1 wherein the ring A may optionally be substituted, R1 represents hydrogen or an N-protecting group, each of R2, R3 and R4 (1) a hydrogen atom, (2) an alkyl group which may optionally be substituted with halogen atom(s) or (3) an alkoxy group which may optionally be substituted with halogen atom(s) or alkoxy; or its salt, is produced by subjecting a solvate of the compound (I) or its salt to de-solvent treatment, in an industrially advantageous method.