103589-67-9

Basic information

• Product Name: 3-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile
• CAS NO: 103589-67-9
• Molecular Weight: 178.621
• Mol File: 103589-67-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile(103589-67-9)
• EPA Substance Registry System: 3-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile(103589-67-9)

Safety Data

• Hazardous Substances Data: 103589-67-9(Hazardous Substances Data)

Upstream product

• 5660-83-3 2-cyclopentylidene malononitrile 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 120-92-3 cyclopentanone 
• 68-12-2 N,N-dimethyl-formamide 
• 88745-35-1 4-Cyano-2,3,5,6-tetrahydro-7H-cyclopenta<1,2-c>pyridin-3-one 

Downstream Products

• 1644599-75-6 methyl 1-(4-phenyl-1H-1, 2,3-triazol-1-yl)-7,8-dihydro-6H-cyclopenta[d]thieno[2,3-b]pyridine-2-carboxylate 
• 2409124-07-6 3-(prop-1-en-2-yl)-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile 
• 2676862-51-2 3-isopropyl-1-methoxy-6,7-dihydro-5H-cyclopenta[c]pyridin-4-amine 
• 2676862-50-1 1-bromo-3-isopropyl-6,7-dihydro-5H-cyclopenta[c]pyridin-4-amine 
• 2409124-11-2 3-isopropyl-6,7-dihydro-5H-cyclopenta[c]pyridine-4-amine 
• 2409124-08-7 3-isopropyl-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile 
• 103589-69-1 3-(3-Isopropyl-2-phenyl-oxazolidin-5-ylmethoxy)-6,7-dihydro-5H-[2]pyrindine-4-carbonitrile 

Relevant articles and documents

ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS

Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.

Synthesis of methyl 3-azidothieno[2,3-b]pyridine-2-carboxylates and application of the huisgen reaction

The preparation of new substituted methyl 3-azidothieno[2,3-b]pyridine carboxylates by azotization of methyl 3-aminothieno[2,3-b]pyridine and subsequent treatment with sodium azide is described. Via Huisgen's 1,3-dipolar cycloaddition between substituted alkynes and the prepared azides, methyl 1,2,3-triazolo-thieno[2,3-b]pyridine carboxylates have been obtained.

A one-pot synthesis of 2-chloronicotinonitriles and fused 2-chloro-3-cyanopyridines

2-Chloronicotinonitriles (2a-d) and fused bi- and tricyclo-2-chloro-3-cyanopyridines (2e-h) are obtained from alkylidenemalononitriles (1a-h) by Vilsmeier reaction.Generation in situ of an aldehyde equivalent species in the Vilsmeier reaction at the γ-carbon with respect to the nitrile carbon of the alkylidenemalononitriles, followed by cylization, both occurring in one-pot, are presumed to be involved in the pyridoannulation.