10359-15-6

Basic information

• Product Name: 2-CYANO-SUCCINIC ACID DIETHYL ESTER
• Synonyms: DIETHYL CYANOSUCCINATE;2-CYANO-SUCCINIC ACID DIETHYL ESTER;RARECHEM AL BS 0236;Diethyl-2-cyanosuccinate;Nsc79189
• CAS NO: 10359-15-6
• Molecular Formula: C₉H₁₃NO₄
• Molecular Weight: 199.2
• Product Categories: Nitro / Nitriles;Miscellaneous
• Mol File: 10359-15-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 316 °C at 760 mmHg
• Flash Point: 137.3 °C
• Appearance: /
• Density: 1.12 g/cm³
• Vapor Pressure: 0.000423mmHg at 25°C
• Refractive Index: 1.443
• CAS DataBase Reference: 2-CYANO-SUCCINIC ACID DIETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYANO-SUCCINIC ACID DIETHYL ESTER(10359-15-6)
• EPA Substance Registry System: 2-CYANO-SUCCINIC ACID DIETHYL ESTER(10359-15-6)

Safety Data

• Hazardous Substances Data: 10359-15-6(Hazardous Substances Data)

Usage

General Description

2-Cyano-succinic acid diethyl ester is a chemical compound that falls under the category of esters, formed through a reaction between an alcohol and an acid. It has a cyano group (CN), which is a functional group consisting of a carbon atom triple-bonded to a nitrogen atom. 2-CYANO-SUCCINIC ACID DIETHYL ESTER may be used in various chemical synthesis processes given its molecular structure and reactivity. However, the specific properties, toxicity and other data related to this compound may vary and need further study for accurate information. Chemically, it’s important to handle this with caution as exposure can have potential health risk depending on its toxicity.

InChI:InChI=1/C9H13NO4/c1-3-13-8(11)5-7(6-10)9(12)14-4-2/h7H,3-5H2,1-2H3

Upstream product

• 773837-37-9 sodium cyanide 
• 105-39-5 chloroacetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 
• 105-56-6 ethyl 2-cyanoacetate 
• 64-17-5 ethanol 
• 18852-51-2 sodium cyanoacetic acid ethyl ester 
• 96-34-4 methyl chloroacetate 
• 151-50-8 potassium cyanide 
• 91248-60-1 diethyl 2-amino-5-methylfuran-3,4-dicarboxylate 

Downstream Products

• 18283-42-6 2-Cyanosuccinamid 

Relevant articles and documents

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SYNTHESIS OF CYANOCARBOXYLIC ACID ALKYL ESTERS

Provided is a process for obtaining a compound of formula (I): N≡C-CH2-A-C(O)-OR, wherein Hal is halogen selected from F, Cl, Br or I, A denotes a bond or a divalent spacer selected from alkylene and arylene groups, and R is a C1-4 alkyl group, by reacting a compound of formula (II): Hal-CH2-A-C(O)-OR, wherein Hal is a halogen atom selected from F, Cl, Br and I, and wherein A and R are as defined above, with hydrogen cyanide in the presence of a first base, wherein the molar ratio between hydrogen cyanide and said first base is from 1:0.3 to 1:0.95 and the molar ratio between hydrogen cyanide to the compound of formula (II) is at least 1:1.

Process for production of 2,5 dioxopyrrolidine 3 carboxylate

The present invention provides a novel intermediate which enable to prepare tetrahydropyrrolo[1,2-a]pyrazin-4-spiro-3′-pyrrolidine derivatives such as Ranirestat being promising therapeutic agents for diabetic complications in a short process and in an economically advantageous and safe manner, and a process for preparing the same. That is, the present invention provides a process for preparing a compound of the following formula (I) wherein R1 is an amino group protected with a protecting group, etc., and R2 is a lower alkyl group, etc., comprising the following steps (1) and (2): (1) a step of converting a cyano group in a compound of the following formula (II) wherein n and m are each independently 0 or 1; provided when n is 0 and m is 1, then R2 and R3 are the same or different protecting groups for a carboxyl group; and when n is 1 and m is 0, then R2 and R3 are the same protecting groups for a carboxyl group; and R1 is as defined above, into a carbamoyl group in the presence of divalent palladium compound(s), primary amide(s) and water; and (2) a step of cyclizing the product obtained in the step (1).