103596-36-7

Basic information

• Product Name: (R,S)-(+/-)-α-methyl-β-(4-fluorophenyl)-N-propynylethylamine
• Synonyms: (R,S)-(+/-)-α-methyl-β-(4-fluorophenyl)-N-propynylethylamine
• CAS NO: 103596-36-7
• Molecular Weight: 191.248
• Mol File: 103596-36-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R,S)-(+/-)-α-methyl-β-(4-fluorophenyl)-N-propynylethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (R,S)-(+/-)-α-methyl-β-(4-fluorophenyl)-N-propynylethylamine(103596-36-7)
• EPA Substance Registry System: (R,S)-(+/-)-α-methyl-β-(4-fluorophenyl)-N-propynylethylamine(103596-36-7)

Safety Data

• Hazardous Substances Data: 103596-36-7(Hazardous Substances Data)

Upstream product

• 459-02-9 4-fluoroamphetamine 
• 106-96-7 propargyl bromide 
• 134538-46-8 1-(4-fluorophenyl)-2-nitropropene 
• 459-57-4 4-fluorobenzaldehyde 
• 444308-32-1 rac-1-(4-fluorophenyl)-2-propanol 
• 459-03-0 4-fluorophenyl acetone 
• 2450-71-7 Propargylamine 

Downstream Products

• 103596-43-6 N-methyl-N-(1-(4-fluoro-phenyl)-2-propyl)-2-propynylamine 

Relevant articles and documents

Direct Alkylation of Amines with Primary and Secondary Alcohols through Biocatalytic Hydrogen Borrowing

The reductive aminase from Aspergillus oryzae (AspRedAm) was combined with a single alcohol dehydrogenase (either metagenomic ADH-150, an ADH from Sphingobium yanoikuyae (SyADH), or a variant of the ADH from Thermoanaerobacter ethanolicus (TeSADH W110A)) in a redox-neutral cascade for the biocatalytic alkylation of amines using primary and secondary alcohols. Aliphatic and aromatic secondary amines were obtained in up to 99 % conversion, as well as chiral amines directly from the racemic alcohol precursors in up to >97 % ee, releasing water as the only byproduct.