1036374-96-5

Basic information

• Product Name: C₂₁H₂₂F₃N₃O₄
• Synonyms: C₂₁H₂₂F₃N₃O₄
• CAS NO: 1036374-96-5
• Molecular Weight: 437.419
• Mol File: 1036374-96-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₂F₃N₃O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₂F₃N₃O₄(1036374-96-5)
• EPA Substance Registry System: C₂₁H₂₂F₃N₃O₄(1036374-96-5)

Safety Data

• Hazardous Substances Data: 1036374-96-5(Hazardous Substances Data)

Upstream product

• 865528-40-1 C₁₉H₂₀FN₃O₄ 
• 74427-22-8 2,2-difluoroethyl triflate 
• 1036375-32-2 2,2-difluoroethyl 3-nitrobenzensulfonate 

Relevant articles and documents

Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)- pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a clinical candidate

A series of (3R,4R)-pyrrolidine-3,4-dicarboxylic acid amides was investigated with respect to their factor Xa inhibitory activity, selectivity, pharmacokinetic properties, and ex vivo antithrombotic activity. The clinical candidate from this series, R1663